Tag Archive: Yoav Dori

Jul 3 2019

Genetic Discovery Leads to New Treatment for Defective Lymphatic Circulation

The findings:

A study team at Children’s Hospital of Philadelphia discovered a gain-of-function mutation in the ARAF gene causing a life-threatening rare disease known as central conducting lymphatic anomaly that disrupts circulation of lymphatic fluid. They also identified an existing drug that acts on biological pathways affected by ARAF. The experimental treatment had dramatic results for a young boy with the disease who had worsening respiratory and swelling problems. The drug blocked the signals causing the dysregulated growth and abnormal lymphatic flow, prompting his lymphatic channels to reshape themselves into more normal anatomy and function.

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Jan 13 2017

CHOP Research In the News: Plastic Bronchitis, NICU Outcomes, Teen Drivers

CHOP Research In the NewsThe year is off to a great start, with plenty of research news to report. This biweekly installment of In the News describes a new study in the emerging field of lymphatics, shares an editorial on advancements in neonatology, and highlights research to keep teen drivers safe.

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Jun 17 2016

CHOP Research In the News: New Sleep Times, Plastic Bronchitis, Exercise and Bone Strength, Military Families’ Healthcare Needs

CHOP Research In the NewsOur news highlights this week include new evidence-based sleep recommendations; a new champion for helping military families navigate children’s healthcare issues; a lifesaving solution to a mysterious surgical side effect; and an encouraging finding to help children predisposed to fragile bones grow up stronger.

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Apr 29 2016

CHOP Research In the News: Plastic Bronchitis, Baby BMI, Voice at the Vatican

CHOP Research In the NewsEvery week is full of discovery at The Children’s Hospital of Philadelphia. Among the highlights this week are a significant discovery and new treatment option in a heart surgery complication that affects young patients; a study of how to predict infants’ later obesity risk; and a CHOP cancer immunotherapy story hitting the world stage at an international conference.

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