Tag Archive: University of Pennsylvania

Nov 21 2018

In the Gut: Therapeutic Discovery in the Microbiome

 


The Fifth Annual Microbiome Symposium: Microbes, Metabolomics, and Modern Diseases highlighted the synergy of the Children’s Hospital of Philadelphia and University of Pennsylvania scientific community to produce incredibly novel and exciting research.

Hosted by the PennCHOP Microbiome Program, the Nov. 8 symposium brought experts from the fields of microbiology, immunology, gastroenterology, cell and molecular physiology, and pathology together with a common goal: to share developments from their labs with the end game of improving outcomes for individuals with chronic disease.

Larry Jameson, MD, PhD, executive vice president, University of Pennsylvania Hospital System and dean of the Perelman School of Medicine, welcomed attendees to the packed Gaulton Auditorium.

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Nov 16 2018

In the News: Vital-Sign Monitors for Infants, Manufacturing Precision Tools for Medicine, Annual Report of Injury Prevention Studies, Penn-CHOP Nutritional Research

At Children’s Hospital of Philadelphia, we know innovation sometimes requires a second look at seemingly harmless practices and a willingness to break out of the status quo. In this edition of In the News, learn how an unnecessary emergency room visit prompted Christopher Bonafide, MD, to examine the use of physiological monitors for healthy infants, and read about a bold move toward future innovation with the grand opening of our new Clinical Manufacturing Facility for precision medical tools. Additionally, the Center for Child Injury and Prevention Studies’ Annual Report highlights important safety work with real-world implications, a new Penn-CHOP collaboration aims to investigate nutritional interventions to treat disease, and a CHOP patient gets the surprise of a lifetime in the name of autism awareness.

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Nov 2 2018

In the News: Fertility After Childhood Cancer, Restoring Vision, NYAS Podcast, Obesity and Autism, Genes in Childhood Epilepsy

The scientific wonder of stem cell research and its implications for medicine have come a long way in the last decade: At Children’s Hospital of Philadelphia Research Institute, our investigators’ innovative use of stem cell science to approach complex pediatric conditions continues to inspire for their potential to improve outcomes in children’s health. In our latest news roundup, learn about novel stem cell research from our Cancer Center and Division of Urology that aims to preserve the future fertility of boys who undergo childhood cancer treatment. Discover a new project co-led by a CHOP neurology researcher that takes a stem cell approach to restore vision cells in blind dogs.

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Oct 8 2018

The Science Behind Gene Therapy: Creating Breakthroughs One Gene at a Time

For more than 20 years, researchers at Children’s Hospital of Philadelphia and the University of Pennsylvania have been at the forefront of taking a system perfected by nature — a virus — and transforming it into breakthrough gene therapies for rare single-gene diseases. CHOP was the first pediatric research institution to develop chimeric antigen receptor T cell (CAR-T) therapy for acute lymphoblastic leukemia. In this approach, viral vectors are used to modify a patient’s own T cells, training them to track down and eliminate the circulating cancer cells.

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Sep 20 2018

Pioneering Novel Therapies for Hemophilia

Editor’s Note: Jacqueline Hunter, PhD, a postdoctoral fellow in the Wolfe Laboratory, wrote this article as part of the Advanced Career Exploration (ACE) Fellowship at Children’s Hospital of Philadelphia Research Institute. The ACE program gives fellows the opportunity to pursue projects beyond their main research focus. We’re especially excited to share Dr. Hunter’s work during National Postdoc Appreciation Week.

Normally, the body responds to a bleeding event by forming a clot, which is a complicated process involving multiple proteins in an elegantly orchestrated cascade. When specific proteins of this cascade are absent, one of several debilitating disorders can occur that result in recurrent spontaneous bleeding into the joints and muscles. Researchers at Children’s Hospital of Philadelphia are using clever maneuvering to figure out new therapeutic options for patients with hemophilia A and B.

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Sep 7 2018

In the News: Parents Magazine, EC Approval of CAR T-Cell Therapy, Impulsive Behavior in Teens

Along with the start of school and settling into new routines, September marks Childhood Cancer Awareness Month: a special time to support cancer research and care for patients and families impacted by the disease. Fittingly, this week’s roundup of research news highlights the remarkable impact our oncologists have made for children with cancer around the world. And on top of that, we highlight new findings that challenge the traditional notion of the teen years as a reckless time of risky behavior.

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Aug 16 2018

What Percentage of Parents Engage in Distracted Driving?

The Findings:

About 50 percent of parents reported talking on their cell phones while driving with their young child in the vehicle, while one in three read text messages, and one in seven used social media, according to online surveys of adults across the U.S. The findings, published in a recent study from our Center for Injury Research and Prevention (CIRP) at Children’s Hospital of Philadelphia and the University of Pennsylvania School of Nursing, also reveal that parents who used their cell phones in the car were more likely to engage in other risky driving behaviors, such as not wearing a seat belt when they were a driver and not consistently using their typical child restraint system (CRS) for their child.

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Jul 27 2018

In the News: ROP Screening Tool, Sickle Cell Disease Target, PolicyLab Keynote, 2018 St. Baldrick’s Grants

It’s still a month before teachers and students are officially back to school, but here at Children’s Hospital of Philadelphia Research Institute, you can learn something new every day. In this edition of our biweekly news roundup, discover the latest findings from our ophthalmologists on how clinicians should choose to screen premature babies for a potentially blinding eye disorder, find out how CRISPR-based technology allowed scientists to reveal insights into sickle cell disease, and prepare for an educational and exciting speech from the recently announced keynote speaker at PolicyLab’s upcoming 10th Anniversary Forum

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Apr 13 2018

Entrepreneurial Science Scholars Turn Ideas Into Medical Innovation

By definition, entrepreneurs are energetic leaders who challenge existing ideas to drive impactful change. Entrepreneurs think outside the box, follow their passion, and stay resilient and resourceful to achieve their goals. At Children’s Hospital of Philadelphia, fellows in the Entrepreneurial Science Scholars Program do all of these things — and more — to improve the health of children and families.

On Feb. 22, we celebrated this year’s CHOP Entrepreneurial Science Scholars, a group of six clinician-researchers who are conducting pioneering research and innovation in diverse and critical fields. The CHOP Entrepreneurial Science Scholars Program aims to produce highly trained investigators skilled in translational research and the generation of creative solutions to biomedical problems. Joseph St. Geme, MD, Physician-in-Chief and Chairman of the Department of Pediatrics at CHOP, hosted the event.

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Apr 6 2018

U.S. News & World Report, David Barrett, Driving & ADHD, Bike Safety, Concussion Research

Outdoor sports, biking, and bustling streets might be welcome signs of warmer weather and longer days, but they’re also research topics studied rigorously by investigators at our Center for Injury Research and Prevention (CIRP) in their quest to ensure safer environments for children and families. In this week’s roundup of Children’s Hospital of Philadelphia research headlines, learn about a new study from CIRP into the various causes and mechanisms of youth concussions beyond contact sports, discover cool technology that allows scientists to study how cyclists move and make decisions on urban streets, and find out how the CIRP driving simulator is helping to advance what we know of teen driving behaviors. On top of that, we congratulate the Cancer Center’s Dr. David Barrett on a new award from Stand Up to Cancer and offer big congratulations to our Department of Pediatrics’ continued success!

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