As the new year approaches, we look back with gratitude for yet another year packed with scientific breakthroughs in children’s health. Continuing a remarkable run for personalized gene therapies, 2018 marked the European Commission’s approval of two gene therapies pioneered at Children’s Hospital of Philadelphia and the University of Pennsylvania, as patients in the European Union (EU) may now be treated with chimeric antigen receptor (CAR)-T cell therapy for aggressive forms of leukemia, and the very first gene therapy developed for inherited blindness.
Tag Archive: Neuroscience
Our latest roundup of research headlines from Children’s Hospital of Philadelphia is all about connecting the dots — whether it’s between two disciplines that come together in a common research mission, or discovering answers to previously unknown research questions. Read on to learn more about the Neuroscience of Driving Research Program, a collaboration between our Center of Injury Research and Prevention (CIRP) and the neuroradiology MEG (magnetoencephalography) Imaging Center at CHOP, along with novel findings that advance our understanding of how the brain processes rewards in individuals with autism spectrum disorder(ASD), and more.
Leading-edge neuroscience techniques are facilitating Children’s Hospital of Philadelphia researchers’ better understanding of how the brain controls bladder function, and their novel insights have earned them special recognition from the neurourology community.
Jason Van Batavia, MD, a urologist and physician-scientist in the Division of Urology at CHOP, is the grand prize winner in the 2018 Diokno-Lapides Essay Contest. His manuscript described a research project focused on optogenetic stimulation of specific neurons in a section of the brainstem called Barrington’s nucleus, which scientists think is an important “command center” for controlling voiding (urination).
What’s going on inside our bodies and brains when we respond to stress? Previously, we covered research into powerful little neuropeptides called orexins that may help regulate an individual’s vulnerability to stress. Now, we dug into fresh research from the lab of Seema Bhatnagar, PhD, an associate professor in the division of Stress Neurobiology at Children’s Hospital of Philadelphia, and conducted by Laura Grafe, PhD, a postdoctoral fellow.
Exploring new methods to eradicate HIV that lingers in brain cells despite conventional antiviral treatment is the focus of a new study by investigators at Children’s Hospital and Temple University.