Tag Archive: National Cancer Institute

Jan 30 2019

Borrowing a Weapon From Leukemia’s Arsenal to Develop New Immunotherapy Approaches

More than six years after Emily Whitehead became the first child to receive chimeric antigen receptor (CAR) T-cell therapy, doctors have had remarkable success in turning the immune systems of even more children with acute lymphoblastic leukemia (ALL) into top-notch fighters against the disease. For some patients, however, these superhero T-cells still fail in their mission to find and fight their cancer targets.

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Jan 9 2019

New Cancer Moonshot Grant Catalyzes Research for Immunotherapy in Childhood Cancer

Creating the opportunity for every child with cancer to enjoy a healthy life beyond their cancer experience is the dream for pediatric oncology researchers. New grants awarded by the National Cancer Institute Moonshot Initiative through a multi-institutional, collaborative group — the  Pediatric Immunotherapy Discovery and Development Network (PI-DDN) —  aim to bring this dream closer to reality by fundamentally changing our understanding of how to harness the power of the immune system to treat childhood cancers.

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Dec 31 2018

Our Most Read Stories of 2018 Celebrate Diversity, Data, and Discovery

As the new year approaches, we look back with gratitude for yet another year packed with scientific breakthroughs in children’s health. Continuing a remarkable run for personalized gene therapies, 2018 marked the European Commission’s approval of two gene therapies pioneered at Children’s Hospital of Philadelphia and the University of Pennsylvania, as patients in the European Union (EU) may now be treated with chimeric antigen receptor (CAR)-T cell therapy for aggressive forms of leukemia, and the very first gene therapy developed for inherited blindness.

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Dec 10 2018

Single Cell Technology Zooms In for Clearer View of High-risk Pediatric Cancers

The voice of Kai Tan, PhD, rises and quickens when he considers the potential of single cell technology to zero in on pathogenesis of cancer and other diseases. He points to the attention this course of research is receiving via funding from organizations such as the National Cancer Institute (NCI) Moonshot Initiative and the Chan Zuckerberg Initiative’s Human Cell Atlas project. In fact, Dr. Tan is himself is a valued contributor to the single cell revolution, and his work will continue with a recent NCI grant for the development of a pediatric tumor cell atlas.

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Oct 23 2018

Data Release to Enable Smarter Trials for Pediatric Cancer: Q&A With John Maris, MD

With the release of over 200 genomic tumor models spanning 25 different types of childhood cancer, researchers may now have the ability to skip lengthy preclinical work in their development of novel treatments. With funding from Alex’s Lemonade Stand Foundation (ALSF), the Pediatric Preclinical Testing Consortium (PPTC) announced their data sets will now be made available to any qualified academic petitioner — a move that John Maris, MD, oncologist at Children’s Hospital of Philadelphia Cancer Center and principal investigator of the PPTC’s CHOP site, believes is the first of its kind.

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Feb 26 2018

John Maris, MD, Receives National Cancer Institute Outstanding Investigator Award

Long before he entered medical school, John M. Maris, MD, pediatric oncologist and the recent recipient of the National Cancer Institute’s Outstanding Investigator Award, became captivated by the mysteries of neuroblastoma. A cancer of the peripheral (not brain) nervous system, neuroblastoma accounts for 7 percent of all childhood cancers and 15 percent of all childhood cancer deaths.

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Sep 22 2017

AAP Conference, PCORI Sickle Cell Research, Eagles Autism Challenge, Anxiety and Autism, New Immunotherapy Target for Neuroblastoma

CHOP Research In the NewsNotable awards, new autism initiatives, and a novel approach to managing sickle cell disease are all part of this week’s roundup of research news.

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Jul 28 2017

Psychology in Media Award, Targeted Cancer Drugs, Dermatology App, CHOP ROP Model, Beckwith-Wiedemann Conference

CHOP Research In the NewsRead on for more exciting headlines from this week, including highlights from our inaugural “Deciphering Beckwith-Wiedemann Syndrome” conference.

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Sep 23 2016

CHOP Research In the News: Emmy Award, Kids and the Cancer Moonshot, Precision Approach to Epilepsy, Concussion Monitoring App

CHOP Research In the NewsThis week we’re all about getting smart in our highlights of research news from The Children’s Hospital of Philadelphia. Getting smart in the approach to tackling childhood cancer means identifying strategies that will make a decade’s progress in half the time.

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