Tag Archive: Immunology

Nov 13 2018

New Center for Computational and Genomic Medicine Harnesses Technology and Big Data for Discovery

The Human Genome Project’s successful completion 15 years ago gave us a new genomic lens to read our 20,000 or so protein-coding genes. Since then, a surge in next-generation sequencing technologies is generating new insights daily that sharpen our view of how the human genome works.

Yi Xing, PhD, was on the cusp of this revolution in medicine as he finished his PhD training in molecular biology and bioinformatics at University of California Los Angeles (UCLA). His research career began to rise during the incredible takeoff of big data science, and he became a prominent scientist in this cutting-edge field. The immense challenges of synthesizing diverse data sets from many sources come with vast opportunities to change pediatric medicine, which is why Dr. Xing is eager to assume his new role as the inaugural director of the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia.

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Oct 16 2018

Steven D. Douglas, MD, Receives 25th Silver Lecture for Pediatric HIV/AIDS Research


With an enterprising career spanning 50 years in basic and clinical immunology and more than 500 publications, Steven D. Douglas, MD, had the honor of presenting the 25th Herman and Gertrude Silver Lecture, in which he reviewed major milestones in the field of pediatric HIV/AIDS and shared his optimism that paradigm shifts and new discoveries are ahead.

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Oct 5 2018

In the News: Silver Award, Supporting Outcomes Research, Hope on Wheels, Home Visiting Programs

As we move full-speed ahead into fall, the new season brings with it a handful of headlines from our researchers at Children’s Hospital of Philadelphia. This week, we share the latest news about investigators who have been recognized for their research legacies and for their current cutting-edge work, from discoveries in the basic and clinical science of HIV/AIDS, to the development of learning health system-based training in outcomes research, to the design of innovative approaches to childhood cancer.

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Aug 8 2018

New FVIII Center Crosses Disciplines to Reach Answers for Hemophilia A

Hematologists have grappled for many years to understand the basic mechanisms underlying why some young patients with the inherited bleeding disorder hemophilia A develop inhibitory antibodies, also known as factor VIII (FVIII) inhibitors, to protein replacement therapy. The presence of FVIII inhibitors is a serious obstacle that makes it difficult and extremely expensive to treat their hemophilia, leads to complications such as joint disease, and increases mortality.

Such a major challenge requires major brain power. So the National Institutes of Health called on the scientific community to reframe the question: Why is FVIII so immunogenic?

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Jun 30 2017

Measuring Flexible Thinking, Managing Concussions, Tech Addiction, 2017 Pew Scholar, U.S. News & World Report

CHOP Research In the NewsEvery good researcher needs a sturdy set of tools: Whether it’s a new technology that drives efficiency, the financial support that accompanies an award, or simple advice from a research mentor, all of these resources make collective breakthroughs possible.

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Aug 26 2016

CHOP Research In the News: Allergies and Asthma, Arthritis, and Immunology of Inflammation

CHOP Research In the NewsThis week’s highlights are an alliterative array to close out the month of August, with a study linking asthma with other allergies and news on progress against arthritis in kids. Plus, an immunology discovery could lead to treatments for inflammatory disorders.

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Jul 13 2016

How Warts Could Reveal the Immune System’s Tiny Flaws and Functions

immune systemMedical students have a classic rule of thumb on the subject of choosing their specialty: If you’re undecided between obstetrics and pediatrics, the moment of truth will happen right after you deliver a baby for the first time. In that exhilarating moment of helping a mother welcome a new life, do you want to stay as the obstetrician at the mom’s bedside, or do you want to follow the baby?

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