Tag Archive: immune system

Mar 2 2018

Exploring the Wide World of the Microbiome

Studying the microbiome — the 40 trillion or so invisible microbes that call your body home — is like being an explorer of a secret world with its own language and lifeforms. Whether these microbes are sometimes friends or sometimes foe depends on subtle interactions with each other and the role of influential factors such as your genetics, environment, age, and diet.

The PennCHOP Microbiome Program awards annual pilot and feasibility grants to help faculty members of the University of Pennsylvania and Children’s Hospital of Philadelphia scientific communities navigate this uncharted territory. With the funding awarded in 2017, eight projects are underway, and CHOP clinician-scientists are leading two of them.

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Jun 30 2016

Scientists Reveal New Mechanism Adenovirus Uses to Sabotage Immune System

adenovirusAdenovirus, a common human virus that usually affects the lungs and causes respiratory tract infections, is an old friend to virologists. They have long studied how this virus interacts with host cells to understand cellular processes and reveal key regulators of cellular functions.

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Apr 21 2016

Putting the Brakes on Allergic Response

allergic responseWhen you have a chronic allergic disorder, it’s easy to blame the trigger — an early pollen season or furry pet — but the real culprit is your own immune system. Designed to attack foreign substances such as bacteria and viruses, T cells are the immune system’s watchdog to recognize serious threats. But sometimes T cells can be too zealous and set in motion a signaling cascade that can cause allergic reactions to everyday things and even attack your body’s healthy cells by mistake.

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Sep 17 2015

Teaching the Immune System to Have Long-term Memory for Leukemia

A CHOP cancer patient adding her colorful symbols of hope to a white car that is covered with children’s handprints from all over the country.Your immune system is designed to protect against foreign invaders such as infections, but you may not realize that it also destroys abnormal cells that your body produces.

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Sep 10 2015

New Gene Variants Found in Very Early Onset Inflammatory Bowel Disease

inflammatory bowel diseaseMelding together genomics technology, disease patterns, immunology, and microbiology, physician-scientists at The Children’s Hospital of Philadelphia are finding new and individualized therapies for patients with very early onset inflammatory bowel disease.

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