Tag Archive: Genes

May 20 2019

Do Mothers’ and Babies’ Genes Influence Birth Weight?

The Findings:

An international research team conducted a large study and learned that genetic factors from both mothers and babies interact to influence birth weight. The researchers identified 190 genetic signals from variants affecting birth weight, of which 129 signals were new discoveries. The researchers also demonstrated that some of the mother’s genes were not inherited by the baby, but they did influence the baby’s uterine environment during pregnancy.

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Dec 9 2015

Genes Found Linking Infants’ Heart Disease and Brain Development

heart diseaseHalf of infants born with severe congenital heart disease go on to develop neurodevelopmental disorders, which may include cognitive, motor, social, and language impairments.

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Nov 5 2014

Collaborative International Study Finds Childhood Epilepsy Genes

childhood epilepsyAn international team of researchers recently identified gene mutations that can cause severe, difficult-to-treat forms of childhood epilepsy. Many of the mutations disrupt functioning in the synapse, the highly dynamic junction at which nerve cells communicate with one another.

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Jun 23 2014

Gene Study Points to Novel Pathway for Diabetes Treatment

New research from The Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania details how a diabetes-related gene functions on a biological pathway that affects the release of insulin.

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Jul 16 2013

CHOP Research Announces New DNA-Protein Interaction Affinity Group

DNA-Protein InteractionSince the completion of the Human Genome Project, there has been a natural surge in biomedical research aimed at gene discovery. Using genome-wide association studies (GWAS), bioinformatics, and other approaches, this process has focused largely on determining what genes are implicated in specific diseases.

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May 17 2013

Study Identifies BMI-Associated Loci in Individuals of African Descent

BMIStruan Grant, PhD, associate director of The Children’s Hospital of Philadelphia’s Center for Applied Genomics (CAG), co-authored a study that discovered new loci associated with body mass index (BMI) in adults of African ancestry.

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Dec 6 2012

CHOP Researchers Identify Two Gene Mutations Linked to Neuroblastoma

NeuroblastomaFor decades, researchers at The Children’s Hospital of Philadelphia have worked to better understand and treat neuroblastoma, a cancer of nerve tissue.Neuroblastoma is frequently aggressive, causing approximately 12 percent of all childhood cancer deaths. In high-risk forms of the disease, the cancer tends to return after initial treatment, often with deadly results.

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