Tag Archive: clinical trials

Sep 20 2018

Pioneering Novel Therapies for Hemophilia

Editor’s Note: Jacqueline Hunter, PhD, a postdoctoral fellow in the Wolfe Laboratory, wrote this article as part of the Advanced Career Exploration (ACE) Fellowship at Children’s Hospital of Philadelphia Research Institute. The ACE program gives fellows the opportunity to pursue projects beyond their main research focus. We’re especially excited to share Dr. Hunter’s work during National Postdoc Appreciation Week.

Normally, the body responds to a bleeding event by forming a clot, which is a complicated process involving multiple proteins in an elegantly orchestrated cascade. When specific proteins of this cascade are absent, one of several debilitating disorders can occur that result in recurrent spontaneous bleeding into the joints and muscles. Researchers at Children’s Hospital of Philadelphia are using clever maneuvering to figure out new therapeutic options for patients with hemophilia A and B.

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Sep 7 2018

In the News: Parents Magazine, EC Approval of CAR T-Cell Therapy, Impulsive Behavior in Teens

Along with the start of school and settling into new routines, September marks Childhood Cancer Awareness Month: a special time to support cancer research and care for patients and families impacted by the disease. Fittingly, this week’s roundup of research news highlights the remarkable impact our oncologists have made for children with cancer around the world. And on top of that, we highlight new findings that challenge the traditional notion of the teen years as a reckless time of risky behavior.

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Jul 27 2018

In the News: ROP Screening Tool, Sickle Cell Disease Target, PolicyLab Keynote, 2018 St. Baldrick’s Grants

It’s still a month before teachers and students are officially back to school, but here at Children’s Hospital of Philadelphia Research Institute, you can learn something new every day. In this edition of our biweekly news roundup, discover the latest findings from our ophthalmologists on how clinicians should choose to screen premature babies for a potentially blinding eye disorder, find out how CRISPR-based technology allowed scientists to reveal insights into sickle cell disease, and prepare for an educational and exciting speech from the recently announced keynote speaker at PolicyLab’s upcoming 10th Anniversary Forum

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Jun 27 2018

Stephen P. Hunger, MD, Receives Prestigious George R. Buchanan Lectureship Award

Stephen P. Hunger, MD

Stephen P. Hunger, MD, has received numerous honors throughout his decorated career. However, winning the George R. Buchanan Lectureship Award from the American Society of Pediatric Hematology/Oncology (ASPHO) had particularly special meaning to the chief of the Division of Oncology and director of the Center for Childhood Cancer Research at Children’s Hospital of Philadelphia.

Recognized internationally in the field of pediatric leukemia clinical care and research, Dr. George R. Buchanan— past president of ASPHO and a renowned pediatric hematology physician-researcher — was very supportive of Dr. Hunger early in his career.

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Jun 15 2018

In the News: Alex’s Lemonade Stand, Button Batteries, Mitochondrial Medicine, Project EVO, Citizen Diplomat Award

CHOP Research In the News

Summer at Children’s Hospital of Philadelphia is definitely off to a sweet start: We kick off this week’s research roundup with a new way of thinking about honey (thanks to novel findings from our ear, nose, and throat specialists) and congratulate the Cancer Center at CHOP on yet another successful day of serving up lemonade to support the Alex’s Lemonade Stand Foundation (ALSF). On top of that, we cover research updates from our Mitochondrial Medicine Frontier Program and the Center for Autism Research (CAR), and share a special new award for Stephan Grupp, MD, PhD, director of the Cancer Immunotherapy Program.

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May 11 2018

Clinical Research Coordinators Get Crowns and Congratulations

Clinical research coordinators are the heart and soul of our research breakthroughs, as many of our investigators and staff at Children’s Hospital of Philadelphia know. Whether they’re ensuring that a study falls within regulatory protocols, explaining the science behind a health condition to a family, or simply spending time with patient participants to put them at ease, coordinators bridge the gap between an idea and its execution, as well as between scientists and the patients whose outcomes they hope to improve.

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Apr 27 2018

“Unique, Different, and Special”: Ben Hartranft Speaks Up for Autism

Nineteen-year-old Ben Hartranft remembers the first research study he participated in at the Center for Autism Research (CAR) nearly eight years ago. Though he was just 12, he didn’t feel nervous or scared about the functional magnetic resonance imaging machine that would capture images of his brain. Instead, Ben’s mom recalls him joking that the researchers could duct tape his legs to the chair to help him keep still (which, of course, wasn’t necessary).

“I just stayed still, and it was very fun,” Ben said.

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Feb 26 2018

John Maris, MD, Receives National Cancer Institute Outstanding Investigator Award

Long before he entered medical school, John M. Maris, MD, pediatric oncologist and the recent recipient of the National Cancer Institute’s Outstanding Investigator Award, became captivated by the mysteries of neuroblastoma. A cancer of the peripheral (not brain) nervous system, neuroblastoma accounts for 7 percent of all childhood cancers and 15 percent of all childhood cancer deaths.

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Nov 13 2017

Strengthening Duchenne Muscular Dystrophy Research: Antonio Rosato

From the time Antonio Rosato was diagnosed with Duchenne muscular dystrophy (DMD) at age 4½, his family was eager for him to participate in a clinical research trial. They wanted to give him access to the latest advances in pharmacological and disease management approaches for DMD, an opportunity that Antonio’s uncle Artie, who was diagnosed with the same neuromuscular disease four decades ago, did not have.

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Nov 3 2017

Weight and CHD, Tumor Biology, I-ACT Grant, Mitochondrial Disease Guidelines

As the November chill settles in, warm up to new scientific discoveries and novel projects for improving children’s health from our researchers at Children’s Hospital of Philadelphia. In our roundup of research headlines, we share the latest findings on the biology of pediatric low-grade gliomas – the most common childhood brain tumor – congratulate Christopher Forrest, MD, in his role as co-investigator of a new FDA-funded clinical trials network, and give you the highlights on two new papers from researchers in mitochondrial medicine and cardiology.

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