“What works?” in healthcare is the driving question for the Center for Pediatric Clinical Effectiveness’ (CPCE) multidisciplinary research team and their new director Alex Fiks, MD, MSCE. The research Center at Children’s Hospital of Philadelphia is dedicated to facilitating, organizing, and centralizing the performance of clinical effectiveness research to discover and share knowledge about best practices in pediatric care.
Tag Archive: Center for Pediatric Clinical Effectiveness
By Nancy McCann
Take a look at who’s been making research headlines lately. This week we’re covering the accuracy of an autism spectrum disorder screening tool; the generous gift for palliative care, treatment, and research; and the international recognition of our Extracorporeal Membrane Oxygenation (ECMO) Center manager, James Connelly.
The cicadas may be “singing,” but the summer season isn’t over quite yet. In the midst of heat waves, drenching rainstorms, and vacation escapes, our investigators continue to advance scientific discovery. In this edition of In The News, Children’s Hospital of Philadelphia researchers report a more sensitive method of detecting genetic material delivered via adeno-associated viral vectors, while another group published findings that could help avoid unnecessary non-culture cerebrospinal fluid infection tests. Meanwhile, Petar Mamula, MD, looks into more effective management of a rare vascular anomaly, and Alex Fiks, MD, assumes a director role within the Research Institute.
It’s that time of year, again! Can you believe it? Before you get caught up in yards of wrapping paper, strings of lights, and mile-long “to-do” lists, take a moment to read this week’s roundup of research news from Children’s Hospital of Philadelphia. You’ll discover best-practices to get toddlers to sleep — and stay asleep — just in time for the holidays! Learn the identity of our sweeter-than-sugar doctor, the correlation of lower blood pressure and smoke-free policies, and the latest on Leigh Syndrome.
Every child with cancer deserves the greatest opportunity to be cured, no matter where in the world they live. This overarching sense of purpose took Julianne Burns, MD, a third-year pediatric Infectious Diseases fellow, from Children’s Hospital of Philadelphia to the Hospital Infantil Dr. Robert Reid Cabral (HIRRC) in the Dominican Republic for four weeks this summer to conduct much needed infectious disease research.
The Findings: Children and adults treated with five classes of oral antibiotics have a significantly higher risk of developing kidney stones. The five classes include oral sulfas, cephalosporins, fluoroquinolones, nitrofurantoin, and broad-spectrum penicillins. Patients who received sulfa drugs were more than twice as likely as those not exposed to antibiotics to have kidney stones. For broad-spectrum penicillins, the increased risk was 27 percent higher. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. The risk of kidney stones decreased over time but remained elevated several years after antibiotic use.
The tide of antibiotic resistance continues to rise worldwide, and it is taking Eimear Kitt, MBBCh BAO (Hons), a third-year fellow in Infectious Diseases, and her study team to Botswana in sub-Saharan Africa this summer to prospectively collect information on antibiotic use in hospitalized children. When they return to Children’s Hospital of Philadelphia and analyze their data, their findings will help to inform strategies to improve antibiotic stewardship in low- and middle-income settings.
For many of our researchers, the annual Pediatric Academic Societies (PAS) Meeting is more than just another conference or convention: It’s an exciting and educational event filled with discovery and discussion about the myriad ways we can improve children’s health. This year, experts from Children’s Hospital of Philadelphia will convene in Toronto from May 5 to 8 for four days of networking, presentations, poster sessions, and awards. They’ll represent a range of pediatric fields — from behavioral health to bone health, injury research to emergency medicine, neonatology to autism spectrum disorder (ASD), and almost everything in between.
Bigger isn’t always better, especially when it comes to combating pediatric infectious disease. Researchers conducted a study that compared the effectiveness of broad-spectrum antibiotic treatment to narrow-spectrum antibiotic treatment for common childhood acute respiratory tract infections (ARTIs). Children who received narrow-spectrum antibiotics had a higher health-related quality of life and a reduced risk of antibiotic side effects as compared to children receiving broad-spectrum antibiotics, according to data from this study.
As summer fades, it’s exciting to embrace a new season filled with vibrant opportunities. The Center for Pediatric Clinical Effectiveness at Children’s Hospital of Philadelphia is ushering in the fall with a call for applications to its Pilot Grant Program. The program aims to support CHOP investigators who are interested in conducting studies designed to gather evidence about novel strategies that could shift current research or a clinical practice paradigm.