Tag Archive: Center for Lymphatic Imaging and Interventions

Jul 3 2019

Genetic Discovery Leads to New Treatment for Defective Lymphatic Circulation

The findings:

A study team at Children’s Hospital of Philadelphia discovered a gain-of-function mutation in the ARAF gene causing a life-threatening rare disease known as central conducting lymphatic anomaly that disrupts circulation of lymphatic fluid. They also identified an existing drug that acts on biological pathways affected by ARAF. The experimental treatment had dramatic results for a young boy with the disease who had worsening respiratory and swelling problems. The drug blocked the signals causing the dysregulated growth and abnormal lymphatic flow, prompting his lymphatic channels to reshape themselves into more normal anatomy and function.

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Jan 13 2017

CHOP Research In the News: Plastic Bronchitis, NICU Outcomes, Teen Drivers

CHOP Research In the NewsThe year is off to a great start, with plenty of research news to report. This biweekly installment of In the News describes a new study in the emerging field of lymphatics, shares an editorial on advancements in neonatology, and highlights research to keep teen drivers safe.

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