Tag Archive: cardiac

May 1 2018

Does an Impaired Biological Pathway Help Explain Heart Problems in Huntington’s Disease?

The Findings:

Researchers gained new insights into the heart problems that are the second leading cause of death in patients with Huntington’s disease (HD). An incurable, inherited disease with progressive loss of brain cells and motor function, HD occurs when a defective gene produces repeated copies of a protein called huntingtin, or HTT. The mutant HTT (mHTT) protein disrupts multiple fundamental cellular processes along the mTORC1 pathway that promotes cell growth and metabolism. The study team described how decreased mTORC1 activity contributed to the development of heart disease with stress in mouse models of HD. By restoring cardiac mTORC1 activity, the researchers improved the animals’ heart function and survival over the course of the study.

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May 26 2015

Fresh Whole Blood Lowers Child Heart Surgery Exposure Risk

heart surgeryInfants and children who undergo heart surgery are better off receiving fresh whole blood transfusions from a single donor, compared to receiving component blood from multiple donors, according to new research from The Children’s Hospital of Philadelphia.

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Feb 22 2013

Some Kids With Heart Defects May Experience Abnormal Growth Regulation

heart defectsChildren who are born with complex heart defects like congenital heart disease can often have poor growth. A new study from a pediatric cardiologist and her team at The Children’s Hospital of Philadelphia suggests that that this poor growth may stem from factors beyond deficient nutrition, and may include abnormalities in overall growth regulation.

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