Tag Archive: cancer immunotherapy

Aug 8 2018

New FVIII Center Crosses Disciplines to Reach Answers for Hemophilia A

Hematologists have grappled for many years to understand the basic mechanisms underlying why some young patients with the inherited bleeding disorder hemophilia A develop inhibitory antibodies, also known as factor VIII (FVIII) inhibitors, to protein replacement therapy. The presence of FVIII inhibitors is a serious obstacle that makes it difficult and extremely expensive to treat their hemophilia, leads to complications such as joint disease, and increases mortality.

Such a major challenge requires major brain power. So the National Institutes of Health called on the scientific community to reframe the question: Why is FVIII so immunogenic?

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Oct 9 2017

From Baking to Biomedicine: Nick Pautler Won’t Let ALL Define Him

Editor’s Note: This occasional blog series features stories of CHOP research heroes who have participated in clinical research studies. Without the generosity and dedication of families, patients, and members of the public who take the time to be a part of research, many trials would not succeed.

Nick Pautler, a biomedical engineering student at the University of Delaware, can tell you how a lot of things work – from the microbial science behind baking sourdough bread, to the intricacy of model railroads, to the way that an army of re-engineered T-cells worked hard to fight the cancer cells in his body this past year.

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Sep 8 2017

CAR-T Cell Approval, Hope on Wheels, Task Force on Pregnant Women, Taking Flight for Autism, NFL Concussion Research, Doug Wallace

CHOP Research In the NewsSeptember marks National Childhood Cancer Awareness Month, and this year at Children’s Hospital of Philadelphia, we kick-started the commemorative period on the heels of exciting news about breakthroughs in pediatric cancer immunotherapy research. Oncology investigators at CHOP also got a big boost in research funding from Hyundai’s nonprofit organization, Hope on Wheels. And that’s only the beginning: Since September marks the return of the football season, we’re thrilled to share the latest headlines on how the National Football League (NFL) is helping to drive concussion research.

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Aug 31 2017

A Moment to Remember: First-of-its-Kind Cancer Treatment Approved by FDA

It was a pivotal moment that has turned into a new era for cancer immunotherapy. On April 17, 2012, Children’s Hospital of Philadelphia researchers for the first time treated a pediatric patient with a cellular therapy that used her own reprogrammed immune cells, called T cells, to attack her aggressive form of blood cancer.

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