We’re sailing into the middle of June with yet another set of exciting headlines, from the fundraising results of this the 2019 Eagles Autism Challenge, to two new awards that support researchers in our Cancer Center at Children’s Hospital of Philadelphia, to novel insights into mental health after a serious injury, and to discoveries about the impact of trauma and poverty on brain development. Read on for the latest CHOP research news!
Tag Archive: Brain development
By Barb Drosey, Nancy McCann, and Jillian Rose Lim
From discussions on early-life adversity to autism spectrum disorder (ASD), the Lifespan Brain Institute (LiBI) delivered a stimulating second symposium April 8, gathering experts across diverse disciplines to share novel research into how brain and behavior develop over a lifetime. Two hundred attendees learned about cutting-edge basic and translational research projects that address a complex and critical question: What are the factors in early life that place some individuals at risk for neuropsychiatric disorders, while others are resilient?
By Sharlene George
While parents busily prepare for the arrival of their newborn in the final stages of pregnancy, life in the womb also is full of activity. The cerebral cortex in the third trimester is maturing rapidly, establishing the complex neuronal connections needed to navigate a wondrous world. Researchers at Children’s Hospital of Philadelphia suggest a new noninvasive method based on diffusion kurtosis metrics could be used to map how the microstructure of brain regions develop during early infancy. This 4-D spatiotemporal cytoarchitectural signature could provide effective imaging markers to help scientists better understand typical and atypical brain development and the emergence of certain brain functions.
Leaders of the Lifespan Brain Institute (LiBI) brought together experts in child and adult psychiatry, and basic and translational science, to delve into the origins of mental illness, during the Institute’s first symposium, “Pathological Antecedents to Neuropsychiatric Disorders.” Throughout the day, 200 attendees learned about how the typical trajectory of brain development and function is derailed in psychiatric disorders at various points throughout life — perhaps as early as in the womb.
LiBI is uniquely positioned as a broad collaboration between Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania that supports research across the fetal-adult continuum, which is a pillar of CHOP Research Institute’s strategic plan.
Half of infants born with severe congenital heart disease go on to develop neurodevelopmental disorders, which may include cognitive, motor, social, and language impairments.
Stem cells have the unique ability to develop, or differentiate, into other kinds of cells in the body. Researchers have now manipulated human stem cells so that they produce the types of brain cells that play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia, and autism.