Tag Archive: basic science

Nov 13 2018

New Center for Computational and Genomic Medicine Harnesses Technology and Big Data for Discovery

The Human Genome Project’s successful completion 15 years ago gave us a new genomic lens to read our 20,000 or so protein-coding genes. Since then, a surge in next-generation sequencing technologies is generating new insights daily that sharpen our view of how the human genome works.

Yi Xing, PhD, was on the cusp of this revolution in medicine as he finished his PhD training in molecular biology and bioinformatics at University of California Los Angeles (UCLA). His research career began to rise during the incredible takeoff of big data science, and he became a prominent scientist in this cutting-edge field. The immense challenges of synthesizing diverse data sets from many sources come with vast opportunities to change pediatric medicine, which is why Dr. Xing is eager to assume his new role as the inaugural director of the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia.

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Dec 5 2017

Three Key Questions for Breaking Into Translational Research

Breakthroughs in basic science build the foundation for clinical research and our treatment of children’s health. Many basic scientists, however, find themselves wanting to play a more active role in connecting their lab discoveries from the bench to the bedside. The Office of Postdoctoral Affairs at Children’s Hospital of Philadelphia held a Q&A panel, “How to Break Into Translational Research As a Basic Scientist,” in October as part of their week-long, biannual Translational Research Workshop.

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Dec 17 2015

Mitochondria Affect How We Respond to Stressful Environments

mitochondriaNew research suggests that the tiny structures inside our cells that generate energy, called mitochondria, may play a role in our mind-body interactions and how we respond to stressful environments.

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Dec 16 2015

Possible ‘Central Hub’ Proteins Found in Cancer Cell Growth

cancer cellA study from researchers at The Children’s Hospital of Philadelphia may add new lines to the textbook description of how cancer cells divide uncontrollably and develop into tumors.

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Nov 4 2015

Tiny Mitochondria Play Outsized Role in Human Evolution and Disease

Cells under microscopeMitochondria are not only the power plants of our cells; these tiny structures also play a central role in our physiology. Furthermore, by enabling flexible physiological responses to new environments, mitochondria have helped humans and other mammals to adapt and evolve throughout the history of life on earth.

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Oct 20 2015

Young Investigator Seeks a Target for Targeted Neuroblastoma Therapy

It is scary to learn your child has neuroblastoma, a tumor of the peripheral nervous system that is the most common cancer in infants. It is scarier still when you get test results that show your child is in the half of neuroblastoma patients whose cancer is very aggressive and high-risk.

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