Tag Archive: neurodevelopmental

Aug 13 2019

How Do Specific Sets of Neurons Influence Autistic-like Features of CDKL5 Deficiency Disorder?

The findings:

Researchers studying CDKL5 deficiency disorder (CDD), a complex and severe neurodevelopmental condition caused by mutations in the CDKL5 gene, gained novel insights into CDD’s underlying mechanisms. Their findings suggest that disrupted early development of neural circuitry has downstream consequences, disturbing neurotransmitter pathways and resulting in cognitive problems and autistic-like behaviors.

Previous research by the scientific team demonstrated that loss of CDKL5, which provides instructions for making a synaptic protein essential for normal brain development and functions, in forebrain glutamatergic neurons is implicated in learning and memory deficits. Their new findings suggest that loss of CDKL5 in forebrain GABAergic neurons leads to autistic-like features in mouse models of CDD.

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