Tag Archive: Michelle Denburg

Mar 29 2019

Collaborating for Pediatric Kidney Disease Clinical Research

By Jillian Rose Lim

Our kidneys work hard to keep us healthy, from regulating fluids, to flushing out waste, to supporting strong, supple bones. Protecting these key functions is especially critical for children, who rely on the all-important organ to keep their bodies growing and nutrients flowing. Thankfully, chronic kidney disease (CKD), in which kidneys sustain progressive and permanent damage over time, is rare in children. But this rarity also means researchers and clinicians need to work harder to gather enough patients and data to mount effective clinical trials and improve outcomes.

And though pediatric CKD is uncommon, the condition can be devastating, leaving a long-term impact on a child’s adult life. The overall life expectancy of children with kidney disease is approximately 40 years less than the average population.

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Jul 10 2018

Do Oral Antibiotics Play a Role in Kidney Stone Prevalence Increase in Youth?

The Findings: Children and adults treated with five classes of oral antibiotics have a significantly higher risk of developing kidney stones. The five classes include oral sulfas, cephalosporins, fluoroquinolones, nitrofurantoin, and broad-spectrum penicillins. Patients who received sulfa drugs were more than twice as likely as those not exposed to antibiotics to have kidney stones. For broad-spectrum penicillins, the increased risk was 27 percent higher. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. The risk of kidney stones decreased over time but remained elevated several years after antibiotic use.

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May 18 2018

Pediheart Podcast, EPA Asthma Award, Walk for Hope, Antibiotics and Kidney Stones, Gilyena Approval, Autism Challenge

In our latest roundup of Children’s Hospital of Philadelphia research headlines, learn how our investigators took their discoveries from the bench to the bedside (and beyond), gaining local and national recognition for their hard-earned advances in interventional cardiology practice, asthma management, multiple sclerosis (MS), and more. On top of that, we give you updates on April’s successful Walk for Hope and share our excitement for this Saturday’s Eagles Autism Challenge — two fun-filled family events that illustrate just how much scientific breakthroughs rely on both the community and our scientists.

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