Tag Archive: Division of Endocrinology and Diabetes

Jun 29 2018

In the News: Neuroscience of Driving, ASD Reward Circuitry, Orthopaedics Meeting, Diva De León-Crutchlow

Our latest roundup of research headlines from Children’s Hospital of Philadelphia is all about connecting the dots — whether it’s between two disciplines that come together in a common research mission, or discovering answers to previously unknown research questions. Read on to learn more about the Neuroscience of Driving Research Program, a collaboration between our Center of Injury Research and Prevention (CIRP) and the neuroradiology MEG (magnetoencephalography) Imaging Center at CHOP, along with novel findings that advance our understanding of how the brain processes rewards in individuals with autism spectrum disorder(ASD), and more.

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Apr 13 2018

Entrepreneurial Science Scholars Turn Ideas Into Medical Innovation

By definition, entrepreneurs are energetic leaders who challenge existing ideas to drive impactful change. Entrepreneurs think outside the box, follow their passion, and stay resilient and resourceful to achieve their goals. At Children’s Hospital of Philadelphia, fellows in the Entrepreneurial Science Scholars Program do all of these things — and more — to improve the health of children and families.

On Feb. 22, we celebrated this year’s CHOP Entrepreneurial Science Scholars, a group of six clinician-researchers who are conducting pioneering research and innovation in diverse and critical fields. The CHOP Entrepreneurial Science Scholars Program aims to produce highly trained investigators skilled in translational research and the generation of creative solutions to biomedical problems. Joseph St. Geme, MD, Physician-in-Chief and Chairman of the Department of Pediatrics at CHOP, hosted the event.

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Mar 6 2018

Is an Uncommon Genetic Mutation Linked to Vitamin D-dependent Rickets?

The Findings:

Researchers identified a genetic mutation in CYP3A4 that is linked to vitamin D-dependent rickets (VDDR), a childhood disorder associated with impaired growth and skeletal mineralization. Scientists already knew about two other genetic forms of VDDR, but this third kind is caused by a gain-in-function mutation — a random genetic change that confers a new function on a gene — that leads to accelerated inactivation of vitamin D metabolites. This is a new insight into vitamin D metabolism.

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