Tag Archive: Division of Cancer Pathobiology

May 1 2019

Can Boosting an Oncogene Make Cancer Cells More Vulnerable to Chemotherapy?

By Sharlene George

The Findings:

Oncogenes such as MYC are notorious troublemakers that promote cancer. Previous research strategies have focused on finding ways to quiet down levels of MYC; however, basic scientists at Children’s Hospital of Philadelphia took the opposite approach. In preclinical models, they increased MYC activity in combination with conventional chemotherapy for Burkitt lymphoma to boost an anti-cancer response. The tumor cells became more sensitive to the drugs, and cancer cell death increased.

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