Tag Archive: Computational method

Mar 26 2019

How Does a New Computational Method Transform Public Big Data Into Knowledge of Transcript Splicing?

By Sharlene George

The findings:

A new computational framework called deep-learning augmented RNA-seq analysis of transcript splicing (DARTS) uses deep-learning based predictions to add dimension to the wealth of information available in public RNA sequencing (RNA-seq) big data sets. DARTS allows researchers to gain new insights into RNA and protein complexity, particularly for genes with low expression.

Who conducted the study:

A team from the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia conducted the study including Yi Xing, PhD, who is the Center’s director, and first authors Zijun Zhang and Zhicheng Pan, who are PhD students.

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Mar 4 2019

New Computational Method Sheds Light on How Genetic Variants Alter RNA Processing

By Sharlene George

A key moment occurs in any gripping novel that sets in motion the characters’ doom or fortune. In the context of gene regulation, RNA-binding proteins (RBPs) play a similar pivotal role determining ribonucleic acid molecules’ (RNAs’) fate by guiding post-transcriptional events. This process is essential to interpretation of genetic code and its function in protein synthesis, which are the building blocks of any organism.

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