Tag Archive: Children’s Hospital of Philadelphia

Feb 18 2019

From Sci-Fi to Real Life, Stefano Rivella, PhD, on the Verge of Discovery

Bundled up in winter clothes from head to toe, 7-year-old Eric rolls a snowball around the backyard with his older brother, building it into a sizeable snowman. Mom, watching from her perch at the kitchen window, can hear her boys laughing — until — Eric doubles over in acute chest pain, crying out for her. Rushing to his side, she wonders how many more of these excruciating episodes and trips to the hospital Eric can endure.

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Feb 14 2019

Researchers Explore How to Promote Firearm Safety in Emergency Department

Pediatric emergency department physicians work at a fast pace to problem solve and provide the right treatment at the right time. Embracing this sense of urgency, physician-researchers with Children’s Hospital of Philadelphia’s Violence Prevention Initiative (VPI) are studying if the ED could be an ideal atmosphere for clinicians to educate patients and families about the risk of firearms, both for unintentional injury and for suicide.

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Feb 8 2019

In the News: Newly Linked Epilepsy Genes, Pediatric Safety Research, Teen Intern Recruits for Research, CHOP Visits UAE, Trends in Opioid Prescription

This week, we highlight the results of innovation powered by collaboration, within Children’s Hospital of Philadelphia Research Institute and around the globe. A multicenter, international consortium revealed genes newly linked to epilepsy, while CHOP CEO Madeline Bell visited Dubai for an interchange of knowledge and technology at the largest medical conference in the world. Closer to home, the Children’s Hospitals’ Solutions for Patient Safety Network, comprised of 135 hospitals in the United States, published its findings on the most effective targets for pediatric patient safety research, and a high school intern helped researchers recruit participants for a teen driving study. Learn about the latest trends in pediatric opioid prescription, and get an update on the Delaney family, whose conjoined twin daughters were separated with painstaking care by a multidisciplinary team at CHOP.

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Feb 1 2019

Why Should We Automatically Reanalyze Genetics Test Results?

The findings:

The human genome contains approximately 20,000 genes, and exome analysis focuses on about 7,000 genes known in medical literature to be clinically associated with a disease. Currently, up to 70 percent of exome test reports are negative or inconclusive. But suppose at a later date a researcher discovers a gene that could be causative of the disease? 

Children’s Hospital of Philadelphia researchers led by Avni Santani, PhD, associate professor of Clinical Pathology, developed a useful tool for automated reanalysis that facilitates efficient reevaluation of nondiagnostic clinical exome sequencing (CES) samples using up-to-date literature published after the initial exome analysis was performed. They demonstrated this methodology enabled identification of novel diagnostic findings in almost 16 percent of previously nondiagnostic samples. 

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Jan 24 2019

New Grant Awarded to Study Driving Among Autistic Teens

As teens transition to adulthood, being able to get around on their own is a big step toward independence, enabling opportunities for social activities, post-secondary education, and work.

But what about this rite of passage for adolescents on the autism spectrum? How does their experience differ from their peers? These are the types of questions Allison Curry, PhD, MPH, wants to answer with the help of a new grant to fund a groundbreaking project that has the potential to help change the lives of many teens and young adults with autism.

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Jan 21 2019

Building the Evidence Base for Treatment of Severe PARDS

Looking into the eyes of a distressed parent, you want to be able to tell them you’re providing interventions that are based on good evidence for the care of their child. When a gap in knowledge prevents that clinical confidence, Martha Curley, RN, PhD, FAAN, pediatric critical care nurse and research scientist, is there to help find answers.

“The main reason I completed a PhD in nursing science was so I could ask and answer questions relevant to the patient population I cared for as a critical care nurse,” said Dr. Curley, professor of nursing and Ruth M. Colket Endowed Chair in Pediatric Nursing, Children’s Hospital of Philadelphia, and professor of anesthesia and critical care medicine, Perelman School of Medicine at the University of Pennsylvania.

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Jan 11 2019

In the News: New Treatment Option for Ph+ ALL, Video Game for Autism and Co-occurring ADHD, Science of Pediatric Palliative Care, Frontier Programs Named

In this edition of In the News, learn about digital medicine and what it means for children with autism spectrum disorder and co-occurring attention deficit/hyperactivity disorder (ADHD). Read about a variation in care study, a recent FDA approved drug treatment for a specific childhood cancer, and why two Children’s Hospital of Philadelphia researchers are calling for improved pediatric palliative care measures. And lastly, join us in celebrating the addition of six new initiatives to CHOP’s Frontier Programs.  

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Jan 9 2019

New Cancer Moonshot Grant Catalyzes Research for Immunotherapy in Childhood Cancer

Creating the opportunity for every child with cancer to enjoy a healthy life beyond their cancer experience is the dream for pediatric oncology researchers. New grants awarded by the National Cancer Institute Moonshot Initiative through a multi-institutional, collaborative group — the  Pediatric Immunotherapy Discovery and Development Network (PI-DDN) —  aim to bring this dream closer to reality by fundamentally changing our understanding of how to harness the power of the immune system to treat childhood cancers.

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Jan 7 2019

Studying ‘The Beginning’ to Understand What Comes Later: Q&A With J. Christopher Edgar, PhD

One-month-old Connor only dimly perceives the world around him. Just two months later, when he sees his mother’s beaming face or hears his father’s hearty laugh, he smiles with recognition. And by the time Connor reaches his first birthday, he’s starting to put one foot in front of the other and verbally communicate with his parents. Just what accounts for these significant changes?

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Dec 28 2018

In the News: Study Tops Most-Read List, the Migratory T Cell Response, Mossé Named Endowed Chair, ‘Healthier Together’ Launches, Supporting Survivors

Leading the charge to develop new, targeted approaches to treat disease, Children’s Hospital of Philadelphia Research Institute investigators have uncovered more of the mechanistic underpinnings of the migratory T cell response, and CHOP announced the inaugural Patricia Brophy Endowed Chair in Neuroblastoma Research to advance innovation into less toxic treatment options for specific cancers. Out in the community, CHOP has teamed up with the Philadelphia Housing Development Corporation for the pilot program of its Healthier Together initiative, and researchers are learning how best to help survivors of violence after they are discharged from the hospital.

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