Feb 26 2013

Using Next-Generation Sequencing to Understand and Treat Disease

next-generation sequencingHow time flies! It seems almost impossible that the many events of 2003 are now almost ten years in the past. It’s also hard to believe that the completion of the Human Genome Project, a government-led initiative involving researchers from all around the world, was nearly a decade ago.

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Feb 22 2013

Some Kids With Heart Defects May Experience Abnormal Growth Regulation

heart defectsChildren who are born with complex heart defects like congenital heart disease can often have poor growth. A new study from a pediatric cardiologist and her team at The Children’s Hospital of Philadelphia suggests that that this poor growth may stem from factors beyond deficient nutrition, and may include abnormalities in overall growth regulation.

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Feb 19 2013

Study Finds Link Between Genes and Lifespan

lifespanSeveral gene variants can influence a person’s potential lifespan by either raising the probability of developing a disease or by providing protection from disease, according to new research from The Children’s Hospital of Philadelphia.

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Feb 15 2013

Searching for the Signs of Autism in Infants

One out of 88 children in the United States has been diagnosed as having an autism spectrum disorder. There is no cure and relatively few treatments that work well for everyone on the autism spectrum. But research, including ground-breaking studies on infants, is making great strides to better understanding autism spectrum disorders.

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Feb 14 2013

Unlocking the Secrets of Mitochondria

mitochondriaA team led by CHOP’s Marni J. Falk, MD, has expanded next-generation gene tools designed to sequence nuclear DNA to analyze a separate source of DNA — that found within mitochondria. Mitochondria are key suppliers of the energy needed for the multiple functions of our cells. Mitochondria contain their own DNA, and play a pivotal role in human health and disease.

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Feb 7 2013

The Cornerstone of Personalized Medicine

personalized medicineThe idea of “personalized” medicine isn’t just about a one-on-one encounter with a doctor, the use of sophisticated mobile applications, or heightened access to healthcare providers, medical records, and services. Personalized medicine also extends into the depths of who each of us are at our essence — to our individual genetic makeup.

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Feb 1 2013

Longer CPR Saves Lives in Children and Adults

CPRTwo recently published studies show that extending cardiopulmonary resuscitation (CPR) longer than previously thought useful saves lives in children and adults. The research teams analyzed the impact of duration of CPR in patients who suffered cardiac arrest while hospitalized.

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Jan 30 2013

Comparing Oral and Intravenous Antibiotics

antibioticsRon Keren, MD, MPH, director of the Center for Pediatric Clinical Effectiveness, was recently awarded nearly two million dollars from the Patient-Centered Outcomes Research Institute (PCORI) to lead a study examining whether oral antibiotics are as effective at treating infection over an extended period as PICC lines.

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