Dec 14 2012

New Study Shows Home Visiting Program May Be Struggling to Reduce Childhood Injuries

PolicyLab_Childhood_injuriesOne of the nation’s largest programs providing home visitation support for at-risk mothers and children may not be as successful in reducing early childhood injuries as it was in earlier evaluations, according to new research findings from the Children's Hospital...

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Dec 12 2012

A Year in Review

The holiday season is once again upon us! While it’s a time for family and friends to gather, indulge in traditions, and celebrate this season of giving, it’s also hard to believe another year has passed.

In another “I can’t believe it’s already here” tradition, the new edition of the Children’s Hospital of Philadelphia Research Institute’s annual report is now available! The 2012 Research Annual Report details some of the many discoveries and accomplishments made at the Research Institute during fiscal year 2012. The report is available both as a PDF and as an interactive Web site.

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Dec 9 2012

Leukemia Patient Cancer-Free After Novel Treatment With Engineered Immune Cells

Emma relapses with acute lymphoblastic leukemia

Dr. Stephen Grupp's patient, Emma, relapses with acute lymphoblastic leukemia (ALL) in April 2011.

Cancer therapy for children has come a long way over the last several decades, and the cure rate for some forms of pediatric cancer is at an all-time high. Although this success rate offers tremendous hope and optimism, there are some children whose disease fails to respond to conventional treatment, leaving doctors to explore novel ways to conquer cancer.

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Dec 6 2012

CHOP Researchers Identify Two Gene Mutations Linked to Neuroblastoma

NeuroblastomaFor decades, researchers at The Children’s Hospital of Philadelphia have worked to better understand and treat neuroblastoma, a cancer of nerve tissue.Neuroblastoma is frequently aggressive, causing approximately 12 percent of all childhood cancer deaths. In high-risk forms of the disease, the cancer tends to return after initial treatment, often with deadly results.

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Dec 5 2012

Genes Linked to Low Birth Weight, Diabetes Risk

Low birth weight, Diabetes riskGenes provide tremendous information about how our bodies work and our possible predisposition for a variety of diseases and conditions. Researchers are working to discern what specific genes and gene regions play a role in disease.

The Children’s Hospital of Philadelphia played a major role in a recent international genetics study that found four new gene regions that contribute to low birth weight. In particular, the investigators found that three of those regions influence metabolism in adults and may play a role in adult height, the risk of type 2 diabetes, and adult blood pressure.

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Dec 4 2012

Welcome to Cornerstone!

Welcome to Cornerstone, the new blog of The Children’s Hospital of Philadelphia Research Institute. We’re really excited to be launching this blog, where we’ll regularly be sharing news, interviews with CHOP investigators, and other commentary related to pediatric health.

The word research comes from the Old French word recercher, which means “to seek out, search closely,” and that’s just what CHOP’s researchers do every day: they seek out knowledge by looking closely at things, in the process helping us better understand the world around us. And research is the cornerstone of medical progress: without it, we wouldn’t have new treatments or medicines.

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