Editor’s Note: Each year, 10,000 patients diagnosed with autism spectrum disorder (ASD) visit a wide range of clinical programs at Children’s Hospital of Philadelphia — including developmental pediatrics, child and adolescent psychiatry, neurology, psychology, speech and language therapy, clinical genetics, general pediatrics, and more. With this enormous patient base and broad sets of expertise across specialties, the Center for Autism Research (CAR) at CHOP offers a tremendous opportunity to conduct rigorous research with its ultimate aim being to improve care, quality of life and long-term outcomes for individuals with ASD.
Neurobiology researchers at Children’s Hospital of Philadelphia are looking deep into the brain’s circuitry to search for new avenues for the treatment of major depressive disorder, the most common mental illness.
In 2016, 10.3 million adults had at least one major depressive episode with severe impairment, according to the National Institute of Mental Health. While care by a health professional and antidepressant medication may be effective for some people, current treatments have a high rate of relapse and side effects.
By definition, entrepreneurs are energetic leaders who challenge existing ideas to drive impactful change. Entrepreneurs think outside the box, follow their passion, and stay resilient and resourceful to achieve their goals. At Children’s Hospital of Philadelphia, fellows in the Entrepreneurial Science Scholars Program do all of these things — and more — to improve the health of children and families.
On Feb. 22, we celebrated this year’s CHOP Entrepreneurial Science Scholars, a group of six clinician-researchers who are conducting pioneering research and innovation in diverse and critical fields. The CHOP Entrepreneurial Science Scholars Program aims to produce highly trained investigators skilled in translational research and the generation of creative solutions to biomedical problems. Joseph St. Geme, MD, Physician-in-Chief and Chairman of the Department of Pediatrics at CHOP, hosted the event.
Editor’s Note: In our Meet Our Investigators series on Cornerstone, get to know our remarkable researchers at Children’s Hospital of Philadelphia Research Institute: a colorful collection of profiles that bring out the personality and passion of faculty members who have recently joined the Research Institute.
Amy Goldstein, MD
Clinical Director, Mitochondrial Medicine Frontier Program and associate professor of Pediatrics in the Division of Human Genetics at the University of Pennsylvania Perelman School of Medicine
Joined the Research Institute:
Cherry Hill, N.J.
Favorite Book or Movie:
“Pride & Prejudice”
Outdoor sports, biking, and bustling streets might be welcome signs of warmer weather and longer days, but they’re also research topics studied rigorously by investigators at our Center for Injury Research and Prevention (CIRP) in their quest to ensure safer environments for children and families. In this week’s roundup of Children’s Hospital of Philadelphia research headlines, learn about a new study from CIRP into the various causes and mechanisms of youth concussions beyond contact sports, discover cool technology that allows scientists to study how cyclists move and make decisions on urban streets, and find out how the CIRP driving simulator is helping to advance what we know of teen driving behaviors. On top of that, we congratulate the Cancer Center’s Dr. David Barrett on a new award from Stand Up to Cancer and offer big congratulations to our Department of Pediatrics’ continued success!
With enormous pride and admiration, we are thrilled to share the news that for the sixth year in a row, U.S. News & World Report has ranked the Department of Pediatrics at Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania first place in pediatric medical education — a top spot shared with Harvard University this year. Once again, the high honor illustrates the excellent commitments our faculty make every day in training physicians and researchers for a future filled with breakthroughs. Congratulations to our amazing Pediatrics Department!
Bigger isn’t always better, especially when it comes to combating pediatric infectious disease. Researchers conducted a study that compared the effectiveness of broad-spectrum antibiotic treatment to narrow-spectrum antibiotic treatment for common childhood acute respiratory tract infections (ARTIs). Children who received narrow-spectrum antibiotics had a higher health-related quality of life and a reduced risk of antibiotic side effects as compared to children receiving broad-spectrum antibiotics, according to data from this study.
Two-year-old Jax Readman might not remember the two open heart surgeries he had at Children’s Hospital of Philadelphia for a complex cardiac defect, but his mom, Haley, looks forward to the day that she can share with Jax all of the positive, powerful, and pretty cool things the family has done to support heart research since his birth.
From the benefits they’ve hosted to support the CHOP Cardiac Center, to the galas attended to share their story for the March of Dimes, Jax will have no shortage of happy memories about how he and his family help to raise money and spread awareness for research into single ventricle heart defects.
Editor’s Note: As part of a pediatric healthcare organization, the Violence Prevention Initiative (VPI) within the Research Institute addresses the antecedents to violence and supports an environment where children feel safe to learn, play, and develop. VPI accomplishes this by implementing hospital-wide and community-based programs, performing clinical research in bullying and violence prevention, providing trauma-informed trainings, and advocating for public policy changes that have implications for children and families.
Along with the first day of spring (though the weather here doesn’t look quite like it just yet), the month of March marks National Nutrition Month — a great time to learn about how research is informing the impact of a healthy diet and lifestyle. This week’s roundup of Children’s Hospital of Philadelphia research headlines includes a recent study from the Division of Gastroenterology, Hepatology, and Nutrition at CHOP along with a handful of fascinating scientific discoveries that tell us new things about pediatric health across the lifespan (and across the skeleton, as you’ll see). Read on for summaries of the latest research from our investigators — from bone health to neurology to mitochondrial medicine and beyond.