May 10 2019

Four CHOP Docs Receive 2019 Perelman School of Medicine Teaching Awards

By Nancy McCann 

It’s Teacher Appreciation Week, and we’re taking our big thinking-caps off to four teachers of excellence honored by the Perelman School of Medicine at the University of Pennsylvania. A total of 18 professors with a penchant for pedagogy were selected for the 2019 teaching awards, and four of the honorees share their talents with Children’s Hospital of Philadelphia and its Research Institute:

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May 9 2019

‘Superheroes’ Receive 2019 Clinical Research Coordinator RE@CH Award

By Nancy McCann 

It was no easy feat for two “superhero” clinical research coordinators (CRCs) to rise to the top of nominees at the 6th annual CRC Research Excellence @ Children’s Hospital (RE@CH) Award ceremony because they were in the company of extraordinaires. 

Congratulations go out to the 2019 CRC RE@CH Award winners Katherine Kellom, a qualitative methods program manager at CHOP’s PolicyLab, and Lindsay Waqar, MPH, CCRC, a clinical research coordinator in the Division of Rheumatology. Their nominating principal investigators were Meredith Matone, DrPH, MHS, and Pamela Weiss, MD, MSCE, respectively.  

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May 8 2019

Exploring Exosome-Mediated Stem Cell Engraftment for Hemoglobinopathies

By Barbara Drosey

Intent on pursuing a career in fetal surgery since age 11, Meghana V. Kashyap, MD, a general surgery resident at the University of Nebraska Medical Center, reached out to five prominent fetal surgery centers to determine where her two years of dedicated research, allowed by her training program, would best be spent.

“Every program I interviewed with had done their training under Dr. (Alan) Flake and his colleagues here at Children’s Hospital of Philadelphia,” Dr. Kashyap said. “I thought, why not train at the institution that produced these other surgeon-scientists?”

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May 3 2019

Where Discovery Leads: Capturing the Complexity of Autism

By Jillian Rose Lim, Nancy McCann, Barbara Drosey, and Sharlene George

Editor’s Note: Where Discovery Leads is a multimedia storytelling project that delves into key research themes at CHOP Research Institute. This is part one of a three-part series that focuses on novel diagnostic tools and approaches being developed under the leadership of the Center for Autism Research at CHOP. See part 2 and part 3 of the series.

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May 3 2019

Where Discovery Leads: New Phone App for Name Recognition to Aid Autism Screening

By Nancy McCann

Editor’s Note: Where Discovery Leads is a multimedia storytelling project that delves into key research themes at CHOP Research Institute. This is part two of a three-part series that focuses on novel diagnostic tools and approaches being developed under the leadership of the Center for Autism Research at CHOP. See part 1 and part 3 of this series.

A child’s diminished response to hearing his or her name has long been recognized as a red flag for autism spectrum disorder (ASD), and now researchers have developed a phone app to quantitatively measure this behavior as a way to help screen for this complex neurodevelopmental diagnosis.

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May 3 2019

Where Discovery Leads: Expanding Access to Diagnosis With ECHO Autism

By Barbara Drosey

Editor’s Note: Where Discovery Leads is a multimedia storytelling project that delves into key research themes at CHOP Research Institute. This is part three of a three-part series that focuses on novel diagnostic tools and approaches being developed under the leadership of the Center for Autism Research at CHOP. See part 1 and part 2 of this series.

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May 1 2019

Can Boosting an Oncogene Make Cancer Cells More Vulnerable to Chemotherapy?

By Sharlene George

The Findings:

Oncogenes such as MYC are notorious troublemakers that promote cancer. Previous research strategies have focused on finding ways to quiet down levels of MYC; however, basic scientists at Children’s Hospital of Philadelphia took the opposite approach. In preclinical models, they increased MYC activity in combination with conventional chemotherapy for Burkitt lymphoma to boost an anti-cancer response. The tumor cells became more sensitive to the drugs, and cancer cell death increased.

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Apr 22 2019

Parents Pair Up With Urban Families to Ease Early Intervention Access

By Barb Drosey

James Guevara, MD, MPH, a passionate advocate for kids’ health and well-being, greets visitors with a warm smile and soft voice. A founding member of PolicyLab at Children’s Hospital of Philadelphia, and senior fellow at the Perelman School of Medicine at the University of Pennsylvania Center for Public Health Initiatives, Dr. Guevara wants to help families connect with early intervention (EI) services to help children experiencing developmental delays get the best start in life.

“The earlier children access EI services, the easier it is to ameliorate developmental delays so, by the time they start kindergarten, they are on a more level playing field with their peers,” Dr. Guevara said.

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Apr 19 2019

In the News: PAS 2019, NFL Helmet Safety, American Society of Gene and Cell Therapy, Bypass Prophylaxis Hemophilia, Lung Disease In Utero

Whether they study helmets on the football field or hemophilia in a lab, our scientists at Children’s Hospital of Philadelphia Research Institute are always on the cutting-edge of their respective fields, as the latest roundup of research news shows. This week, read about what to expect at next week’s Pediatric Academic Societies Meeting, discover how a CHOP engineer is helping to make the NFL safer, and learn about new results from our Center for Fetal Research about treating lung diseases in utero.

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Apr 17 2019

On the Road to Better Treatments for Obese Asthmatics

By Nancy McCann

Ten year-old Jack looks longingly out his living room window, yearning to play kickball with his friends. But mom doesn’t want his asthma to flare up, which it tends to do when he runs around. As much as he wants to go outside, he won’t, because he knows how uncomfortable he gets when his chest starts to tighten. Instead, Jack spends hours on the couch in front of the television, playing video games.

This reinforcing cycle keeps churning — exercise and outdoor play are great for combatting Jack’s obesity, but they’re bad for his asthma. Sitting around begets more weight troubles, but it doesn’t cause him breathing discomfort. Around and around it goes.

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