Oct 6 2017

Neuroblastoma Gene Variants, Center for GI Motility Expansion, Improving Autism Diagnosis, Fontan Procedure Follow-Ups

CHOP Research In the NewsThis week, new research findings at Children’s Hospital of Philadelphia are propelling the way we think about autism, single ventricle survivors, and neuroblastoma forward, as our investigators continued to push the boundaries of what we know.

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Oct 3 2017

What Are Transcription Errors’ Role in Aging and Disease?

The human genome provides a precise, biological blueprint of life. To implement this blueprint correctly, the genome must be read with great precision, but it’s impossible for this process to be completely error-free. Mistakes during transcription — random errors in how DNA sequences are copied for a gene to be expressed — can happen any time in any number of ways.

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Sep 29 2017

Researchers Win Grants to Explore New Drug Targets for Childhood Cancers

National Childhood Cancer Awareness Month is coming to a close, but new research endeavors are continuing the momentum and driving toward better treatment options.

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Sep 26 2017

Bringing it All Together: Organization Skills for Upper Elementary Students

Summer vacation is over, and the kids have strapped on their backpacks and headed back to school for what parents and teachers hope will be a fruitful year.

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Sep 22 2017

AAP Conference, PCORI Sickle Cell Research, Eagles Autism Challenge, Anxiety and Autism, New Immunotherapy Target for Neuroblastoma

CHOP Research In the NewsNotable awards, new autism initiatives, and a novel approach to managing sickle cell disease are all part of this week’s roundup of research news.

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Sep 19 2017

Are Teens Still Building Bone After Attaining Their Adult Height?

The Finding:

Bone mineral accrual doesn’t keep pace with height growth prior to adolescence, according to a national study. After a teenager reaches adult height, bone mineral accrual tends to play catch-up: Roughly 10 percent of bone mass continues to accumulate after height growth is complete. The study findings also suggest that bone growth is site-specific, with bone mineral density developing at different rates in different parts of the skeleton.

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Sep 14 2017

Neonatal Research for Future Families: Research Hero Clay Maresca Gives Back

Editor’s Note: This occasional blog series features stories of CHOP research heroes who have participated in clinical research studies. Without the generosity and dedication of families, patients, and members of the public who take the time to be a part of research, many trials would not succeed.

Meet Clay Maresca: The happy, healthy 2 ½-year-old loves to wear hats (which mom, Amy, loves to buy for him), play with balls, and has a throwing arm so strong it surprises everyone he meets.

But Clay didn’t begin life with the physical strength he wows people with today. When he was just a 25-weeks-and-3-day-old fetus, Amy’s uterus ruptured, and she and her husband, Rob, were faced with the possibility that Clay would be born premature. Placed in a frightening situation, Amy and Rob decided to transfer to Children’s Hospital of Philadelphia Newborn Care at the Hospital of the University of Pennsylvania. They wanted to take advantage of CHOP’s rich research background – faced with the potential that their baby would need special care and attention.

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Sep 12 2017

Driving Evidence-Based Neonatology Forward: A Q&A With Barbara Schmidt, MD

As a student at McMaster University in Canada, Barbara Schmidt, MD, attending neonatologist at Children’s Hospital of Philadelphia, and director of Clinical Research, Neonatology at Penn Medicine, met William A. Silverman, MD, for the first time. Known as the father of neonatal intensive care, Dr. Silverman had given a talk that inspired Dr. Schmidt in its rigorous and questioning approach to newborn research and care: Both Dr. Silverman and Dr. Schmidt believed that nothing but the sharpest evidence should back the decisions we make when treating sick infants. Though she didn’t know it at the time, decades later, Dr. Schmidt would give a lecture on the same subject – one that, in fact, was in Dr. Silverman’s honor.

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Sep 8 2017

CAR-T Cell Approval, Hope on Wheels, Task Force on Pregnant Women, Taking Flight for Autism, NFL Concussion Research, Doug Wallace

CHOP Research In the NewsSeptember marks National Childhood Cancer Awareness Month, and this year at Children’s Hospital of Philadelphia, we kick-started the commemorative period on the heels of exciting news about breakthroughs in pediatric cancer immunotherapy research. Oncology investigators at CHOP also got a big boost in research funding from Hyundai’s nonprofit organization, Hope on Wheels. And that’s only the beginning: Since September marks the return of the football season, we’re thrilled to share the latest headlines on how the National Football League (NFL) is helping to drive concussion research.

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Sep 6 2017

CPCE Putting Research Into Practice With Pilot Grant Program

As summer fades, it’s exciting to embrace a new season filled with vibrant opportunities. The Center for Pediatric Clinical Effectiveness at Children’s Hospital of Philadelphia is ushering in the fall with a call for applications to its Pilot Grant Program. The program aims to support CHOP investigators who are interested in conducting studies designed to gather evidence about novel strategies that could shift current research or a clinical practice paradigm.

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