Jul 12 2019

In The News: Self-Driving Cars; Mother-Infant Dyad; Families’ Health Insurance; One Drug, Two Bone Diseases; Proteomic Dataset; Cancer Patients Quit Tobacco

The Fourth of July fireworks may be over, but sparks are still sizzling (along with the weather) here at the Research Institute as we celebrate our researchers’ published work. Take a look at who’s been in the press lately. This week we’re covering the decision factors behind allowing children to ride alone in self-driving cars, commentary on improving perinatal care in the United States, and why private sector working families are turning to Medicaid and CHIP for health coverage. 

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Jul 10 2019

Off Campus: ‘It’s Been a Hard Day’s Night, and I’ve Been Working Like a Dog’

By Nancy McCann

Editor’s note: We’ve started a new occasional blog series! Do you ever wonder what our super-docs and super-staff do on the weekends, during their downtime? Well, our Research Communications team did, and we created “Off Campus” to discover what our amazing Research Institute employees do for fun, recreation, and the good of their communities. Get a glimpse into their lives once they take off their capes … umm, we mean lab coats and business shoes. And if you know someone in your department or lab with a fascinating hobby or interest, we’d like to hear about it!

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Jul 8 2019

Where Discovery Leads: Building Better Strategies to Protect the Brain From HIV

By Barb Drosey, Jillian Rose Lim, Nancy McCann, and Sharlene George

Editor’s Note: Where Discovery Leads is a multimedia storytelling project that delves into key research themes at CHOP Research Institute. This is part one of a two-part series that focuses on the suite of scientific studies aimed at better understanding the neuropathogenesis of HIV infection on cognitive and intellectual development. See part two of this series.

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Jul 8 2019

Building Community Support for Mental Health and HIV in Botswana

By Jillian Rose Lim

Editor’s Note: Where Discovery Leads is a multimedia storytelling project that delves into key research themes at CHOP Research Institute. This is part two of a two-part series that focuses on the suite of scientific studies aimed at better understanding the neuropathogenesis of HIV infection on cognitive and intellectual development and to improve support services for affected children and adolescents. See part one of this series.

Youth living with HIV in limited-resource settings face unique challenges when it comes to mental health. In Botswana, a country with one of the highest HIV prevalence rates in the world, few accessible places exist for children and adolescents to receive mental healthcare.

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Jul 3 2019

Genetic Discovery Leads to New Treatment for Defective Lymphatic Circulation

The findings:

A study team at Children’s Hospital of Philadelphia discovered a gain-of-function mutation in the ARAF gene causing a life-threatening rare disease known as central conducting lymphatic anomaly that disrupts circulation of lymphatic fluid. They also identified an existing drug that acts on biological pathways affected by ARAF. The experimental treatment had dramatic results for a young boy with the disease who had worsening respiratory and swelling problems. The drug blocked the signals causing the dysregulated growth and abnormal lymphatic flow, prompting his lymphatic channels to reshape themselves into more normal anatomy and function.

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Jun 28 2019

In the News: Driving and Autism, Epilepsy Learning System, Youth-onset Diabetes, Mitochondrial Research Award, MicroRNA and Obesity, Well-being Measures

Even as the lazy days of summer approach, our researchers are busy making news with innovations in their respective fields. In this edition of In The News, a multidisciplinary study lauds parental support as key for autistic adolescents who want to drive, Children’s Hospital of Philadelphia announces a pioneering partnership in the Epilepsy Learning Healthcare System, and the TODAY study shows youth-onset type 2 diabetes leads to later complications. 

For more summer reading, Dr. Douglas Wallace is honored for mitochondrial research; scientists find a correlation among gut microbiota, microRNA 181 (miR-181), and obesity; and a validated pediatric tool for self-reported outcomes becomes available for clinical use.

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Jun 21 2019

Off Campus: Shall We Dance?

By Nancy McCann

Editor’s note: We’ve started a new occasional blog series! Do you ever wonder what our super-docs and super-staff do on the weekends, during their downtime? Well, our Research Communications team did, and we created “Off Campus” to discover what our amazing Research Institute employees do for fun, recreation, and the good of their communities. Get a glimpse into their lives once they take off their capes … umm, we mean lab coats and business shoes. And if you know someone in your department or lab with a fascinating hobby or interest, we’d like to hear about it

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Jun 20 2019

National Distinction Awarded to CHOP Divisions

By Jillian Rose Lim

We are proud to share that Children’s Hospital of Philadelphia has once again been ranked one of the nation’s Best Children’s Hospitals by U.S.News & World Report, marking the 15th consecutive year that our divisions have received top-notch distinctions. CHOP secured second place in the 2019-2020 Honor Roll of Best Children’s Hospitals, a list that seeks to provide an answer to the question that crosses almost every family’s mind: “Which hospitals are best prepared to care for the sickest kids?”

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Jun 18 2019

Novel Approaches to Data Analysis Lead to Discovery at SAGES

By Barbara Drosey

Recognizing the importance of providing context for the rapid advances in whole exome and genome sequencing, data collection, and biological information, Marcella Devoto, PhD, developed the Symposium on Advances in Genomics, Epidemiology, and Statistics (SAGES) with colleagues at the University of Pennsylvania, Princeton University, Johns Hopkins University, Columbia University, and the National Human Genome Research Institute to create a space for colleagues to address these analytical challenges.

“One of its major strengths is the span of research in the areas of genomics that SAGES covers, from statistical methods to clinical applications,” said Dr. Devoto, a researcher in the division of Human Genetics at CHOP and professor of Pediatric, Genetics, and Epidemiology at Penn.

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Jun 14 2019

In the News: Eagles Autism Challenge, ASCO Young Investigator, Innovation in Collaboration, Trauma and Development, Post-Injury Mental Health, AWHONN Award

We’re sailing into the middle of June with yet another set of exciting headlines, from the fundraising results of this the 2019 Eagles Autism Challenge, to two new awards that support researchers in our Cancer Center at Children’s Hospital of Philadelphia, to novel insights into mental health after a serious injury, and to discoveries about the impact of trauma and poverty on brain development. Read on for the latest CHOP research news!

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