Aug 8 2018

New FVIII Center Crosses Disciplines to Reach Answers for Hemophilia A

Hematologists have grappled for many years to understand the basic mechanisms underlying why some young patients with the inherited bleeding disorder hemophilia A develop inhibitory antibodies, also known as factor VIII (FVIII) inhibitors, to protein replacement therapy. The presence of FVIII inhibitors is a serious obstacle that makes it difficult and extremely expensive to treat their hemophilia, leads to complications such as joint disease, and increases mortality.

Such a major challenge requires major brain power. So the National Institutes of Health called on the scientific community to reframe the question: Why is FVIII so immunogenic?

Read the rest of this entry >>

Aug 3 2018

Martha Curley, RN, PhD, ‘Challenges the Givens’ Through Nursing Research

Editor’s Note: In our Meet Our Investigators series on Cornerstone, get to know our remarkable researchers at Children’s Hospital of Philadelphia Research Institute: a colorful collection of profiles that bring out the personality and passion of faculty members who have recently joined the Research Institute.

Name: Martha A.Q. Curley, RN, PhD

Title: Ruth M. Colket Endowed Chair in Pediatric Nursing

Joined the Research Institute: January 2018. I have been on the faculty at University of Pennsylvania School of Nursing for past 11 years, with a joint appointment in Anesthesia and Critical Care Medicine at the Perelman School of Medicine at the University of Pennsylvania.

Hometown: Springfield, Mass.

Read the rest of this entry >>

Aug 1 2018

Curious to Confident: Students Bask in Summer Research Experience

Six students from local under-resourced schools eagerly swapped sunglasses for safety goggles and got to work this summer in some of the most sophisticated research laboratories on campus at Children’s Hospital of Philadelphia Research Institute.

The students navigated real-world research settings, practiced lab skills, explored scientific and medical career options, and met mentors who are dedicated to advancing pediatric medicine, as part of the six-week CHOP Research Internship for Scholars and Emerging Scientists (CHOP-RISES) summer internship. The new program is offered by the Office of Academic Training and Outreach Programs (ATOP) at the Research Institute.

Read the rest of this entry >>

Jul 27 2018

In the News: ROP Screening Tool, Sickle Cell Disease Target, PolicyLab Keynote, 2018 St. Baldrick’s Grants

It’s still a month before teachers and students are officially back to school, but here at Children’s Hospital of Philadelphia Research Institute, you can learn something new every day. In this edition of our biweekly news roundup, discover the latest findings from our ophthalmologists on how clinicians should choose to screen premature babies for a potentially blinding eye disorder, find out how CRISPR-based technology allowed scientists to reveal insights into sickle cell disease, and prepare for an educational and exciting speech from the recently announced keynote speaker at PolicyLab’s upcoming 10th Anniversary Forum

Read the rest of this entry >>

Jul 20 2018

Charting a Course for Children With Kidney Disease

Susan Furth, MD, PhD

Children are not just little adults”: It’s a phrase heard often in pediatric medicine, whether you’re a parent, doctor, or researcher. With their dynamically developing bodies, unique psychology and biolochronic kidney disease (CKD) is just one example of a condition whose causes, consequences, and outcomes differ distinctly from adults. And at Children’s Hospital of Philadelphia, clinician-researchers in our Division of Nephrology are constantly learning more about the important differences between pediatric and adult CKD.,>

Read the rest of this entry >>

Jul 18 2018

CHOP’s Inflammatory Bowel Disease Symposium Attracts Leading Experts

With the rate of inflammatory bowel disease (IBD) continuing to rise, especially in the hard-the-treat population of young children, the timing couldn’t be better for the Children’s Hospital of Philadelphia’s “Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics, and Beyond” symposium.

This symposium was of particular interest because of the unique combination of the latest research developments with the most up to date advances in clinical care for very-early-onset inflammatory bowel disease (VEO-IBD) and pediatric IBD, said course Co-director Judith R. Kelsen, MD, director of CHOP’s Very Early Onset Inflammatory Bowel Disease Clinic.

Read the rest of this entry >>

Jul 16 2018

Team Huddles and Positive Feedback Enhance Research Participant Recruitment

Editor’s Note: Our guest blogger, Lindsay Waqar, MPH, CCRC, is the lead clinical research coordinator for the Division of Rheumatology at Children’s Hospital of Philadelphia. In this guest blog, she describes a collaborative quality improvement project presented at the Eighth Annual CHOP Quality and Safety Day between her research team and clinical fellows’ team to improve communication and research recruitment across the division.

What happens when researchers and clinicians team up to improve the identification of eligible research patients newly diagnosed with a chronic condition? Areas of change are discussed, low effort/high impact interventions are implemented, and research recruitment rates improve. This was the goal of the Division of Rheumatology’s fellow quality improvement project for FY18.

Read the rest of this entry >>

Jul 13 2018

In the News: ALSF Epidemiology Grant, Button Battery Guidelines, PolicyLab Anniversary, EHR-Phenolyzer, Distracted Driving

In this week’s roundup of headlines at Children’s Hospital of Philadelphia, our research takes a leap into real-world applications. Learn how a study from ear, nose, and throat experts at CHOP helped to inform new button battery injury guidelines from the National Poison Center, why a software tool that mines through genomics data can improve genetic diagnoses, and what PolicyLab plans to achieve at their upcoming 10thanniversary forum, “Charting New Frontiers in Children’s Health Policy and Practice.” Don’t miss a chance to discover the latest in research news!

Read the rest of this entry >>

Jul 10 2018

Do Oral Antibiotics Play a Role in Kidney Stone Prevalence Increase in Youth?

The Findings: Children and adults treated with five classes of oral antibiotics have a significantly higher risk of developing kidney stones. The five classes include oral sulfas, cephalosporins, fluoroquinolones, nitrofurantoin, and broad-spectrum penicillins. Patients who received sulfa drugs were more than twice as likely as those not exposed to antibiotics to have kidney stones. For broad-spectrum penicillins, the increased risk was 27 percent higher. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. The risk of kidney stones decreased over time but remained elevated several years after antibiotic use.

Read the rest of this entry >>