A slight chill on the air and the rustling of falling leaves means it’s time to grab your favorite pumpkin spice beverage and read our latest roundup of research news. Investigators from Children’s Hospital of Philadelphia’s Center for Injury Prevention and Research shared findings in concussion research and preventing car crashes among teens. Scientists in the Raymond G. Perelman Center for Cellular and Molecular Therapeutics discovered a gene that could help guide future treatment for schizophrenia, and a pilot grant from the Center for Pediatric Clinical Effectiveness will support aims to improve pre-transplant communication with patients and their families. As you savor the last few sips from your cup, learn about CHOP researchers’ contributions to a special journal issue on baby brain development.
Life after leaving research training is an open road for postdoctoral fellows full of potential career opportunities. Some involve innovative research in academia and industry, and others include exciting new responsibilities in non-research positions. At Children’s Hospital of Philadelphia Research Institute, our postdocs go on to become teaching-focused faculty, consultants, principal investigators, journal editors, and in some cases, all of the above.
To celebrate the 10th anniversary of National Postdoc Appreciation Week — and to guide current and future postdocs who might have a big question mark when it comes to their career paths — we connected with four former postdoctoral fellows who utilize the unique experience they gained at CHOP in a variety of different roles. Scroll down for some words of wisdom and inspiration from our postdoctoral alumni!
By Nancy McCann
Editor’s note: Welcome to our new blog series, “Off Campus.” Here you’ll discover what our amazing Research Institute employees do for fun, recreation, and the good of their communities once they leave the city behind. And if you know someone in your department or lab with a fascinating hobby or interest, we’d like to hear about it!
By Jillian Rose Lim
Whether it’s a road closure on the morning commute or new responsibilities at work, we’re constantly faced with opportunities to use our cognitive flexibility, the ability to shift gears and think up new solutions. But for those who struggle with serious conditions such as eating disorders or depression, improving this executive function could have a major impact on treatment outcomes.
It’s time to say goodbye to summer and settle into days with a little more structure (and a little less humidity). It’s also Childhood Cancer Awareness month, a special time to raise awareness for pediatric cancer research and recognize the researchers who work toward discovering causes and developing treatments. In this week’s research news roundup, learn how scientists in our Cancer Center contributed to the approval of a new cancer drug to treat solid and brain tumors, join us in welcoming our new Chief of Infectious Diseases, learn about new discoveries into stress resilience, and more.
Editor’s Note: Genetic counselors interpret genetic test results to guide and support patients seeking information about their personal and family health. They can take a variety of roles, from meeting with patients in a hospital or clinical care setting, to working in a diagnostic laboratory, to performing primary research. In this guest blog, Sarah Raible, MS, CGC, a senior genetic counselor and clinical director of the Center for Cornelia de Lange Syndrome and Related Diagnoses Center within the Roberts Individualized Medical Genetics Center (RIMGC) at Children’s Hospital of Philadelphia, discusses how genetic counselors’ unique contributions and insights are helping to shape the future of precision medicine.
By Barbara Drosey
Editor’s note: Welcome to our new blog series! “Off Campus” is where you’ll discover what our amazing Research Institute employees do for fun, recreation, and the good of their communities once they leave the city behind. And if you know someone in your department or lab with a fascinating hobby or interest, we’d like to hear about it!
As director of the Congenital Hyperinsulinism Center at Children’s Hospital of Philadelphia, Diva De León-Crutchlow, MD, MSCE, leads a combined clinical and research program aimed to treat patients with hyperinsulinism through medical management or surgical intervention.
Take a look at who’s been in the press lately. This week we’re covering physician-endorsed parent-teen talks, the high rate of success with ultrasound-guided intravenous line placement, and how moms with postpartum depression are being helped with a social media-based parenting program.
Physician Endorsed ‘Birds and the Bees’ Parent-teen Talk may Prove Effective
New research shows that brief parent-targeted interventions in the primary care setting can increase communication between parents and their teens about sexual and alcohol behavior. This method may serve as an important strategy for parents to influence adolescent behaviors and health outcomes.
The Arcus team at the Research Institute is solving a number of challenges at once: Decrease the time it takes for researchers to access data, increase the reproducibility of research, ensure data security, and speed up the rate of breakthroughs. Will Struebing loves that his role as supervisor of Scientific Computing for the Department of Biomedical and Health Informatics (DBHi) pulls him in many directions. In this fourth in a series of Cornerstone posts about the convergence of talent and expertise to build Arcus — an internal program that is providing findable, reusable, trustworthy research data — find out more about Struebing and how his DevOps team is enabling cloud-first development efforts.
Researchers studying CDKL5 deficiency disorder (CDD), a complex and severe neurodevelopmental condition caused by mutations in the CDKL5 gene, gained novel insights into CDD’s underlying mechanisms. Their findings suggest that disrupted early development of neural circuitry has downstream consequences, disturbing neurotransmitter pathways and resulting in cognitive problems and autistic-like behaviors.
Previous research by the scientific team demonstrated that loss of CDKL5, which provides instructions for making a synaptic protein essential for normal brain development and functions, in forebrain glutamatergic neurons is implicated in learning and memory deficits. Their new findings suggest that loss of CDKL5 in forebrain GABAergic neurons leads to autistic-like features in mouse models of CDD.