Category Archive: Children's Hospital of Philadelphia Research Institute

Dec 14 2018

In the News: Gene Therapy EU Approval, Long-Term CAR T-cell Effectiveness, 10 Years of CAR, AHA Conference, CAR T-cell Resistance

The end of the year inevitably arrives with a handful of things to celebrate, from memorable moments to astounding achievements to milestones made. With less than three weeks left in 2018, our list of celebratory moments at Children’s Hospital of Philadelphia Research Institute continues to grow, as this edition of our biweekly research news roundup shows. Read on to learn about two gene therapies pioneered at CHOP and the University of Pennsylvania that recently reached important milestones, a novel discovery from our scientists that could help to improve cancer immunotherapies, the 10-year anniversary of our Center for Autism Research, and more.

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Dec 5 2018

Out of the Darkness: New Grant Awarded to Study Stem Cell Therapy for Vision Restoration

Dora can feel the brisk chill of the wind on her cheeks and hear the crunch of fallen leaves underfoot, but gone from sight are the autumnal colors. An inherited disease that causes blindness robbed her of vision years ago. But, if John Wolfe, VMD, PhD, has anything to do with it, she’ll see the vibrant reds and golden yellows of the season, once again.

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Dec 3 2018

From Big Dreams to Big Data in Pediatrics: Q&A With Jeff Pennington

Children’s Hospital of Philadelphia and its Research Institute has the ability to explore pediatric data better than almost anywhere else in the world to solve challenging problems in child health. In his new role as associate vice president and chief research informatics officer at the Research Institute, Jeff Pennington sees a “don’t miss” window opening where CHOP is at the right time with the right tools, infrastructure, people, and skills in place to launch Arcus, an integrated data science platform.

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Nov 30 2018

In the News: Sleeping Toddlers, No-Smoking Policies and Lower Blood Pressure, Dr. “Be My Sugar,” Leigh Syndrome, Healthcare Heroes Award

It’s that time of year, again! Can you believe it? Before you get caught up in yards of wrapping paper, strings of lights, and mile-long “to-do” lists, take a moment to read this week’s roundup of research news from Children’s Hospital of Philadelphia. You’ll discover best-practices to get toddlers to sleep — and stay asleep — just in time for the holidays! Learn the identity of our sweeter-than-sugar doctor, the correlation of lower blood pressure and smoke-free policies, and the latest on Leigh Syndrome.

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Nov 16 2018

In the News: Vital-Sign Monitors for Infants, Manufacturing Precision Tools for Medicine, Annual Report of Injury Prevention Studies, Penn-CHOP Nutritional Research

At Children’s Hospital of Philadelphia, we know innovation sometimes requires a second look at seemingly harmless practices and a willingness to break out of the status quo. In this edition of In the News, learn how an unnecessary emergency room visit prompted Christopher Bonafide, MD, to examine the use of physiological monitors for healthy infants, and read about a bold move toward future innovation with the grand opening of our new Clinical Manufacturing Facility for precision medical tools. Additionally, the Center for Child Injury and Prevention Studies’ Annual Report highlights important safety work with real-world implications, a new Penn-CHOP collaboration aims to investigate nutritional interventions to treat disease, and a CHOP patient gets the surprise of a lifetime in the name of autism awareness.

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Nov 6 2018

Realizing the Promise of Gene Therapy: Q&A With Clinical Vector Core Directors

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Oct 16 2018

Steven D. Douglas, MD, Receives 25th Silver Lecture for Pediatric HIV/AIDS Research


With an enterprising career spanning 50 years in basic and clinical immunology and more than 500 publications, Steven D. Douglas, MD, had the honor of presenting the 25th Herman and Gertrude Silver Lecture, in which he reviewed major milestones in the field of pediatric HIV/AIDS and shared his optimism that paradigm shifts and new discoveries are ahead.

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Oct 1 2018

What are Best Practices for Pediatric Nasogastric Tube Placement and Verification?

The findings:

Researchers have published best practice recommendations for nasogastric (NG) tube location placement and verification in pediatric patients. Endorsed by the American Society for Parental and Enteral Nutrition (ASPEN), the recommendations include: provide education; use appropriate NGT placement and securing methods; measure gastric pH; consider a radiograph for any patient in whom there is a concern for correct NGT placement; and improve interpretation and communication about the radiograph.

Why it matters:

Upto this point, no standard for the NG tube insertion procedure existed in the United States. If performed improperly, the common practice has potentially serious or fatal complications, including tubes being placed in the child’s lung or snaking into the brain. In addition, the tube can be inserted into the small intestine rather than the intended target of the stomach.

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Sep 21 2018

In the News: Brain Cancer Gene Therapy, 2019 Eagles Autism Challenge, Mitochondrial DNA in Cardiomyopathy, Kids First DRC, Device Symposium

Fall weather and football season have returned to us here at Children’s Hospital of Philadelphia Research Institute, bringing with them a fresh batch of research headlines. In this edition of our biweekly news roundup, catch up on the latest announcements for the second annual Eagles Autism Challenge, learn about new insights into the role mitochondrial DNA plays in heart disease progression, and stay updated on how CHOP helps to drive medical innovation and entrepreneurship forward in the Philadelphia community and beyond.

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Aug 1 2018

Curious to Confident: Students Bask in Summer Research Experience

Six students from local under-resourced schools eagerly swapped sunglasses for safety goggles and got to work this summer in some of the most sophisticated research laboratories on campus at Children’s Hospital of Philadelphia Research Institute.

The students navigated real-world research settings, practiced lab skills, explored scientific and medical career options, and met mentors who are dedicated to advancing pediatric medicine, as part of the six-week CHOP Research Internship for Scholars and Emerging Scientists (CHOP-RISES) summer internship. The new program is offered by the Office of Academic Training and Outreach Programs (ATOP) at the Research Institute.

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