Category Archive: Division of Endocrinology and Diabetes

Apr 13 2018

Entrepreneurial Science Scholars Turn Ideas Into Medical Innovation

By definition, entrepreneurs are energetic leaders who challenge existing ideas to drive impactful change. Entrepreneurs think outside the box, follow their passion, and stay resilient and resourceful to achieve their goals. At Children’s Hospital of Philadelphia, fellows in the Entrepreneurial Science Scholars Program do all of these things — and more — to improve the health of children and families.

On Feb. 22, we celebrated this year’s CHOP Entrepreneurial Science Scholars, a group of six clinician-researchers who are conducting pioneering research and innovation in diverse and critical fields. The CHOP Entrepreneurial Science Scholars Program aims to produce highly trained investigators skilled in translational research and the generation of creative solutions to biomedical problems. Joseph St. Geme, MD, Physician-in-Chief and Chairman of the Department of Pediatrics at CHOP, hosted the event.

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Mar 6 2018

Is an Uncommon Genetic Mutation Linked to Vitamin D-dependent Rickets?

The Findings:

Researchers identified a genetic mutation in CYP3A4 that is linked to vitamin D-dependent rickets (VDDR), a childhood disorder associated with impaired growth and skeletal mineralization. Scientists already knew about two other genetic forms of VDDR, but this third kind is caused by a gain-in-function mutation — a random genetic change that confers a new function on a gene — that leads to accelerated inactivation of vitamin D metabolites. This is a new insight into vitamin D metabolism.

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Jul 8 2016

CHOP Research In the News: Asthma Insurance and Monitoring, Cancer Survivors’ Endocrine Abnormalities

CHOP Research NewsMany research projects aim to keep things on track, from healthcare expenditures to patients’ long-term health. Make certain that you know of the research happenings this week at The Children’s Hospital of Philadelphia by reading on for more highlights.

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Mar 25 2016

CHOP Research In The News: Quantum Award, Bone Health, Antibiotics and Weight Gain

CHOP Research In the NewsNews abounds this first week of spring, and we bring you fresh insights from new scientific studies cultivated by experts at The Children’s Hospital of Philadelphia. But first, take a moment to celebrate a special award that recognizes the dedication of pediatric oncologist Richard Aplenc, MD, PhD, MSCE.

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Mar 24 2016

Researchers Examine Obesity, Cardiovascular Risks in Down Syndrome

Down Syndrome Children with Down syndrome (also known as Trisomy 21) are prone to obesity. Their families may be concerned about their future risks for cardiovascular problems as well as their quality of life.

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Sep 3 2015

Mitochondrial Disease and Diabetes Good Companions in Research

MitochondriaCertain defects in the way the mitochondria work may lead to diabetes, and the ways our bodies adapt to high blood sugars share many features with the ways our bodies respond to mitochondrial disease.

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