Category Archive: Division of Cancer Pathobiology

May 1 2019

Can Boosting an Oncogene Make Cancer Cells More Vulnerable to Chemotherapy?

By Sharlene George

The Findings:

Oncogenes such as MYC are notorious troublemakers that promote cancer. Previous research strategies have focused on finding ways to quiet down levels of MYC; however, basic scientists at Children’s Hospital of Philadelphia took the opposite approach. In preclinical models, they increased MYC activity in combination with conventional chemotherapy for Burkitt lymphoma to boost an anti-cancer response. The tumor cells became more sensitive to the drugs, and cancer cell death increased.

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Mar 9 2016

Coming in for a Landing: A Moonshot Initiative Q&A

moonshot_initiativeVice President Joe Biden’s ambitious “Moonshot” initiative is aimed at boosting and streamlining cancer research across the country. We asked Andrei Thomas-Tikhonenko, PhD, chief of the Division of Cancer Pathobiology and an investigator for the Center for Childhood Cancer Research at The Children’s Hospital of Philadelphia, to share his thoughts on how this strategic plan is changing the landscape of pediatric cancer research.

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Jul 9 2015

Researchers Aim to Find New Pathway Interactions in Colorectal Cancers

colorectal cancerColorectal cancer mainly exists in people older than 50, but it also can occur in young adults who have a genetic condition called familial adenomatous polyposis (FAP).

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