August 2019

Monthly Archive: August 2019

Aug 30 2019

Off Campus: Out of the Lab and Into the Kitchen

By Barbara Drosey

Editor’s note: Welcome to our new blog series! “Off Campus” is where you’ll discover what our amazing Research Institute employees do for fun, recreation, and the good of their communities once they leave the city behind. And if you know someone in your department or lab with a fascinating hobby or interest, we’d like to hear about it!

As director of the Congenital Hyperinsulinism Center at Children’s Hospital of Philadelphia, Diva De León-Crutchlow, MD, MSCE, leads a combined clinical and research program aimed to treat patients with hyperinsulinism through medical management or surgical intervention.

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Aug 23 2019

In The News: ‘The Birds and the Bees,’ Ultrasound-guided IV Line Placement, First CHOPS Syndrome Symposium, Social Media-based Parenting Program, Bystander CPR

Take a look at who’s been in the press lately. This week we’re covering physician-endorsed parent-teen talks, the high rate of success with ultrasound-guided intravenous line placement, and how moms with postpartum depression are being helped with a social media-based parenting program.

Physician Endorsed ‘Birds and the Bees’ Parent-teen Talk may Prove Effective 

New research shows that brief parent-targeted interventions in the primary care setting can increase communication between parents and their teens about sexual and alcohol behavior. This method may serve as an important strategy for parents to influence adolescent behaviors and health outcomes.

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Aug 16 2019

Serving Up Reproducible, Shareable Research: Q&A With Will Struebing

The Arcus team at the Research Institute is solving a number of challenges at once: Decrease the time it takes for researchers to access data, increase the reproducibility of research, ensure data security, and speed up the rate of breakthroughs. Will Struebing loves that his role as supervisor of Scientific Computing for the Department of Biomedical and Health Informatics (DBHi) pulls him in many directions. In this fourth in a series of Cornerstone posts about the convergence of talent and expertise to build Arcus — an internal program that is providing findable, reusable, trustworthy research data — find out more about Struebing and how his DevOps team is enabling cloud-first development efforts.

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Aug 13 2019

How Do Specific Sets of Neurons Influence Autistic-like Features of CDKL5 Deficiency Disorder?

The findings:

Researchers studying CDKL5 deficiency disorder (CDD), a complex and severe neurodevelopmental condition caused by mutations in the CDKL5 gene, gained novel insights into CDD’s underlying mechanisms. Their findings suggest that disrupted early development of neural circuitry has downstream consequences, disturbing neurotransmitter pathways and resulting in cognitive problems and autistic-like behaviors.

Previous research by the scientific team demonstrated that loss of CDKL5, which provides instructions for making a synaptic protein essential for normal brain development and functions, in forebrain glutamatergic neurons is implicated in learning and memory deficits. Their new findings suggest that loss of CDKL5 in forebrain GABAergic neurons leads to autistic-like features in mouse models of CDD.

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Aug 9 2019

In the News: Advancing Gene Therapy, CSF Tests, Managing Vascular Anomalies, New CPCE Director

The cicadas may be “singing,” but the summer season isn’t over quite yet. In the midst of heat waves, drenching rainstorms, and vacation escapes, our investigators continue to advance scientific discovery. In this edition of In The News, Children’s Hospital of Philadelphia researchers report a more sensitive method of detecting genetic material delivered via adeno-associated viral vectors, while another group published findings that could help avoid unnecessary non-culture cerebrospinal fluid infection tests. Meanwhile, Petar Mamula, MD, looks into more effective management of a rare vascular anomaly, and Alex Fiks, MD, assumes a director role within the Research Institute. 

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Aug 7 2019

Meet Eight High School Students Spending Their Summer With Science

By Jillian Rose Lim

School might be out for the summer, but science is still in for eight high school students participating in a unique six-week program called the Children’s Hospital of Philadelphia Research Internship for Scholars and Emerging Scientists (CHOP-RISES). Offered by the Office of Academic Training and Outreach Programs, CHOP-RISES gives students typically underrepresented in science the opportunity to work in some of our most innovative research laboratories and explore a variety of careers in science and medicine. 

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Aug 2 2019

CHOP Psychologists Aim to Enhance Classroom Culture From the Inside Out

By Jillian Rose Lim

For many girls, middle school comes with more challenges than just tests, tryouts, and tough grades. While the best of friendships can develop during the preteen years, it’s also a period prone to “mean girl” culture as gossip, rumors, and bullying abound.

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