September 2018

Monthly Archive: September 2018

Sep 20 2018

Pioneering Novel Therapies for Hemophilia

Editor’s Note: Jacqueline Hunter, PhD, a postdoctoral fellow in the Wolfe Laboratory, wrote this article as part of the Advanced Career Exploration (ACE) Fellowship at Children’s Hospital of Philadelphia Research Institute. The ACE program gives fellows the opportunity to pursue projects beyond their main research focus. We’re especially excited to share Dr. Hunter’s work during National Postdoc Appreciation Week.

Normally, the body responds to a bleeding event by forming a clot, which is a complicated process involving multiple proteins in an elegantly orchestrated cascade. When specific proteins of this cascade are absent, one of several debilitating disorders can occur that result in recurrent spontaneous bleeding into the joints and muscles. Researchers at Children’s Hospital of Philadelphia are using clever maneuvering to figure out new therapeutic options for patients with hemophilia A and B.

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Sep 18 2018

Studying Racial and Ethnic Disparities in Leukemia: Q&A with Richard Aplenc, MD

Acute myeloid leukemia (AML), the second most common leukemia in children, affects different populations of pediatric patients in different ways. With the support of a new Epidemiology Grant from Alex’s Lemonade Stand Foundation, Richard Aplenc, MD, PhD, assistant vice president and chief clinical research officer at Children’s Hospital of Philadelphia, is leading a powerful research project based on the automated extraction of data to learn more about racial and ethnic disparities observed in African American children with AML.

“We’ve known for a long time that African American children do worse with treatment for acute myeloid leukemia than non-African American children,” Dr. Aplenc said. “But we’ve never really understood why that is, and there are a lot of different possibilities.”

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Sep 14 2018

Examining Hospitals’ Role in Preventing Youth Suicide

Editor’s Note: September marks National Suicide Prevention Awareness Month, a time to recognize and promote the different ways that we as a community can help prevent suicide. At PolicyLab, a Center of Emphasis at Children’s Hospital of Philadelphia Research Institute, our researchers study the key role that hospitals, schools, health systems, and other community institutions play in safeguarding the mental health of children and adolescents. In this guest blog post, originally appearing on PolicyLab’s blog, Stephanie Doupnik, MD, MSHP, a faculty member at PolicyLab, co-director of the inpatient Medical Behavioral Unit at CHOP, and an instructor of Pediatrics at the University of Pennsylvania, discusses her four-year research project to identify the most effective suicide prevention practices for young people hospitalized for a suicide attempt.

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Sep 12 2018

Preview PolicyLab’s 10th Anniversary Forum: Q&A With David Rubin

Regional and national leaders in children’s health policy will convene in Old City, Philadelphia Oct. 22 to celebrate the 10th anniversary of PolicyLab, a Center of Emphasis at Children’s Hospital of Philadelphia Research Institute. Never one to sit on the sidelines, PolicyLab has evolved over the last decade to become an energetic force in evidence-to-action reform, shaping the policies and practices that impact the health and well-being of children and families across the country.

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Sep 7 2018

In the News: Parents Magazine, EC Approval of CAR T-Cell Therapy, Impulsive Behavior in Teens

Along with the start of school and settling into new routines, September marks Childhood Cancer Awareness Month: a special time to support cancer research and care for patients and families impacted by the disease. Fittingly, this week’s roundup of research news highlights the remarkable impact our oncologists have made for children with cancer around the world. And on top of that, we highlight new findings that challenge the traditional notion of the teen years as a reckless time of risky behavior.

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