March 2018

Monthly Archive: March 2018

Mar 29 2018

Heart to Heart: How the Readman Family Supports Cardiac Research

Two-year-old Jax Readman might not remember the two open heart surgeries he had at Children’s Hospital of Philadelphia for a complex cardiac defect, but his mom, Haley, looks forward to the day that she can share with Jax all of the positive, powerful, and pretty cool things the family has done to support heart research since his birth.

From the benefits they’ve hosted to support the CHOP Cardiac Center, to the galas attended to share their story for the March of Dimes, Jax will have no shortage of happy memories about how he and his family help to raise money and spread awareness for research into single ventricle heart defects.

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Mar 27 2018

Violence Prevention Initiative Reinforces How Research Helps to Keep Kids Safe

Editor’s Note: As part of a pediatric healthcare organization, the Violence Prevention Initiative (VPI) within the Research Institute addresses the antecedents to violence and supports an environment where children feel safe to learn, play, and develop. VPI accomplishes this by implementing hospital-wide and community-based programs, performing clinical research in bullying and violence prevention, providing trauma-informed trainings, and advocating for public policy changes that have implications for children and families.

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Mar 23 2018

Soy-based Formula Infants, Bone Strength Genetics, Infant Epilepsy, Intravenous Arginine, Concussion Conference

Along with the first day of spring (though the weather here doesn’t look quite like it just yet), the month of March marks National Nutrition Month — a great time to learn about how research is informing the impact of a healthy diet and lifestyle. This week’s roundup of Children’s Hospital of Philadelphia research headlines includes a recent study from the Division of Gastroenterology, Hepatology, and Nutrition at CHOP along with a handful of fascinating scientific discoveries that tell us new things about pediatric health across the lifespan (and across the skeleton, as you’ll see). Read on for summaries of the latest research from our investigators — from bone health to neurology to mitochondrial medicine and beyond.

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Mar 21 2018

Lifespan Brain Institute Symposium Digs Into Roots of Mental Illness

Leaders of the Lifespan Brain Institute (LiBI) brought together experts in child and adult psychiatry, and basic and translational science, to delve into the origins of mental illness, during the Institute’s first symposium, “Pathological Antecedents to Neuropsychiatric Disorders.” Throughout the day, 200 attendees learned about how the typical trajectory of brain development and function is derailed in psychiatric disorders at various points throughout life — perhaps as early as in the womb.

LiBI is uniquely positioned as a broad collaboration between Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania that supports research across the fetal-adult continuum, which is a pillar of CHOP Research Institute’s strategic plan.

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Mar 9 2018

Lung Stem Cells, 2021 Congress of the ISTH, Backseat Safety, Pan-Cancer Analysis, Gates Cambridge Scholarship

From the discovery of stem cells that multiply after a lung injury, to new data that advances how we think about (and treat) childhood cancer, our first roundup of March is packed with discovery. Read on to learn how our researchers stay at the forefront of pediatric science with a new study that expands what scientists know about the body’s extraordinary ability to regenerate, a pan-cancer project that distinguishes how cancer develops in children versus adults, and a handful of updates on what our investigators have in store for the near future.

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Mar 6 2018

Is an Uncommon Genetic Mutation Linked to Vitamin D-dependent Rickets?

The Findings:

Researchers identified a genetic mutation in CYP3A4 that is linked to vitamin D-dependent rickets (VDDR), a childhood disorder associated with impaired growth and skeletal mineralization. Scientists already knew about two other genetic forms of VDDR, but this third kind is caused by a gain-in-function mutation — a random genetic change that confers a new function on a gene — that leads to accelerated inactivation of vitamin D metabolites. This is a new insight into vitamin D metabolism.

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Mar 2 2018

Exploring the Wide World of the Microbiome

Studying the microbiome — the 40 trillion or so invisible microbes that call your body home — is like being an explorer of a secret world with its own language and lifeforms. Whether these microbes are sometimes friends or sometimes foe depends on subtle interactions with each other and the role of influential factors such as your genetics, environment, age, and diet.

The PennCHOP Microbiome Program awards annual pilot and feasibility grants to help faculty members of the University of Pennsylvania and Children’s Hospital of Philadelphia scientific communities navigate this uncharted territory. With the funding awarded in 2017, eight projects are underway, and CHOP clinician-scientists are leading two of them.

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