Dec 14 2018

In the News: Gene Therapy EU Approval, Long-Term CAR T-cell Effectiveness, 10 Years of CAR, AHA Conference, CAR T-cell Resistance

The end of the year inevitably arrives with a handful of things to celebrate, from memorable moments to astounding achievements to milestones made. With less than three weeks left in 2018, our list of celebratory moments at Children’s Hospital of Philadelphia Research Institute continues to grow, as this edition of our biweekly research news roundup shows. Read on to learn about two gene therapies pioneered at CHOP and the University of Pennsylvania that recently reached important milestones, a novel discovery from our scientists that could help to improve cancer immunotherapies, the 10-year anniversary of our Center for Autism Research, and more.

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Dec 12 2018

All in the Family: Parents Meaningfully Engaged in Pediatric Research Consortium

Clinician-researchers in the Pediatric Research Consortium (PeRC) at Children’s Hospital of Philadelphia didn’t have to look far to find specialists to provide novel insights into their research projects: They are the families who are the experts on their children visiting CHOP’s primary care practices.

Four parents from different backgrounds, levels of education, and geographic areas partnered with PeRC in 2013 as a Parent Advisory Board to provide meaningful input to guide implementation of PeRC’s portfolio of research studies. PeRC is a 31-practice, two-state research network with 205 physicians and 41 nurse practitioners who have published about 200 peer-reviewed accepted published manuscripts over the last decade or so.

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Dec 11 2018

Finding a Path to Success: Mentorship Award Recognizes Kristy Arbogast, PhD

When young investigators bring big ideas to Kristy Arbogast, PhD, this year’s winner of the Award for Excellence in Mentoring Research Trainees, she is eager to help them figure out their research vision from the ground up. That’s because Dr. Arbogast knows firsthand the value early career mentors have in shaping how investigators learn to interrogate a scientific problem, analyze the data, and use the results to improve the world.

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Dec 10 2018

Single Cell Technology Zooms In for Clearer View of High-risk Pediatric Cancers

The voice of Kai Tan, PhD, rises and quickens when he considers the potential of single cell technology to zero in on pathogenesis of cancer and other diseases. He points to the attention this course of research is receiving via funding from organizations such as the National Cancer Institute (NCI) Moonshot Initiative and the Chan Zuckerberg Initiative’s Human Cell Atlas project. In fact, Dr. Tan is himself is a valued contributor to the single cell revolution, and his work will continue with a recent NCI grant for the development of a pediatric tumor cell atlas.

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Dec 7 2018

Center for Autism Research Reaches a Decade of Scientific Insights, Leadership

The Center for Autism Research at Children’s Hospital of Philadelphia is celebrating a decade of conducting autism research to understand the causes of autism spectrum disorder, develop effective therapies, and train the next generation of master clinicians and scientists in state-of-the-science best practices for autism screening, diagnosis, and treatment.

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Dec 5 2018

Out of the Darkness: New Grant Awarded to Study Stem Cell Therapy for Vision Restoration

Dora can feel the brisk chill of the wind on her cheeks and hear the crunch of fallen leaves underfoot, but gone from sight are the autumnal colors. An inherited disease that causes blindness robbed her of vision years ago. But, if John Wolfe, VMD, PhD, has anything to do with it, she’ll see the vibrant reds and golden yellows of the season, once again.

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Dec 3 2018

From Big Dreams to Big Data in Pediatrics: Q&A With Jeff Pennington

Children’s Hospital of Philadelphia and its Research Institute has the ability to explore pediatric data better than almost anywhere else in the world to solve challenging problems in child health. In his new role as associate vice president and chief research informatics officer at the Research Institute, Jeff Pennington sees a “don’t miss” window opening where CHOP is at the right time with the right tools, infrastructure, people, and skills in place to launch Arcus, an integrated data science platform.

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Nov 30 2018

In the News: Sleeping Toddlers, No-Smoking Policies and Lower Blood Pressure, Dr. “Be My Sugar,” Leigh Syndrome, Healthcare Heroes Award

It’s that time of year, again! Can you believe it? Before you get caught up in yards of wrapping paper, strings of lights, and mile-long “to-do” lists, take a moment to read this week’s roundup of research news from Children’s Hospital of Philadelphia. You’ll discover best-practices to get toddlers to sleep — and stay asleep — just in time for the holidays! Learn the identity of our sweeter-than-sugar doctor, the correlation of lower blood pressure and smoke-free policies, and the latest on Leigh Syndrome.

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Nov 28 2018

Global Health Researchers Address Neurodevelopmental Impact of HIV in Botswana

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Nov 21 2018

In the Gut: Therapeutic Discovery in the Microbiome

 


The Fifth Annual Microbiome Symposium: Microbes, Metabolomics, and Modern Diseases highlighted the synergy of the Children’s Hospital of Philadelphia and University of Pennsylvania scientific community to produce incredibly novel and exciting research.

Hosted by the PennCHOP Microbiome Program, the Nov. 8 symposium brought experts from the fields of microbiology, immunology, gastroenterology, cell and molecular physiology, and pathology together with a common goal: to share developments from their labs with the end game of improving outcomes for individuals with chronic disease.

Larry Jameson, MD, PhD, executive vice president, University of Pennsylvania Hospital System and dean of the Perelman School of Medicine, welcomed attendees to the packed Gaulton Auditorium.

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