Tag Archive: sickle cell disease

Aug 15 2014

Forced Looping Viable Strategy to Reverse Globin Switch

Investigators at The Children’s Hospital of Philadelphia are exploring a new gene therapy approach that aims to reactivate the production of fetal hemoglobin as a potential intervention for patients with sickle cell disease.

Permanent link to this article: http://blog.research.chop.edu/forced-looping-viable-strategy-reverse-globin-switch/

Jun 13 2014

Exploring Vitamin Supplementation and Disease

Kelly A. Dougherty, PhD recently received an award from the NIH that will support her investigation of vitamin A supplementation and sickle cell disease.

Permanent link to this article: http://blog.research.chop.edu/exploring-vitamin-supplementation-disease/

Jan 14 2014

Flipping a Gene Switch Reactivates Fetal Hemoglobin, May Reverse Sickle Cell Disease

Hematologists have long sought to reactivate fetal hemoglobin as a treatment for children and adults with sickle cell disease (SCD). Researchers at CHOP have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period.

Permanent link to this article: http://blog.research.chop.edu/flipping-gene-switch-reactivates-fetal-hemoglobin-may-reverse-sickle-cell-disease/

Sep 19 2013

On the Cusp of a Cure – Sickle Cell Disease

Sickle cell disease affects millions of people worldwide and is the most common inherited disorder in African Americans, of whom 1 in 375 is born with the disease.

Permanent link to this article: http://blog.research.chop.edu/on-the-cusp-of-a-cure-sickle-cell-disease/

Mar 11 2013

Improving Sickle Cell Care in the U.S. and Abroad

In a recent interview with the National Initiative for Children’s Healthcare Quality (NICHQ), Kwaku Ohene-Frempong, MD, Doctor Emeritus of CHOP’s Comprehensive Sickle Cell Center, discussed his work with sickle cell disease.

Permanent link to this article: http://blog.research.chop.edu/improving-sickle-cell-care-in-the-u-s-and-abroad/