Oct 25 2016

Mentorship in Medicine, Zebras, and Holsteins: Q&A with Elaine Zackai

mentorshipA common adage in medical training goes, “When you hear hoofbeats, think horses (not zebras).” For most doctors in conventional practice, that means that exotic explanations are rarely right. The most prosaic diagnosis for a patient’s symptoms is usually the correct one.

Elaine Zackai, MD, surrounds herself with zebras. In medical practice, Dr. Zackai routinely discovers zebras when treating patients with the rarest and most complex, and often unknown, genetic disorders, as director of Clinical Genetics at the Children’s Hospital of Philadelphia. In her office, she is surrounded with the motif of zebras, from plush toys and figurines to picture frames and the pictures within them — tchotchkes of every stripe, all zebra-striped.

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Permanent link to this article: http://blog.research.chop.edu/mentorship-medicine-zebras-holsteins-qa-elaine-zackai/

Oct 21 2016

CHOP Research In the News: Cancer Moonshot Yields Data-Sharing Initiatives, Hemophilia Surprise, Mitochondrial Medal

CHOP Research In the NewsBuckle your seatbelts because this has been a busy week for research news at Children’s Hospital of Philadelphia. (It was also Teen Driver Safety Week, a topic we touched on with one of our blog posts earlier this week and in last week’s In the News post.) Cancer research is hitting the accelerator with the release of the national Cancer Moonshot Initiative’s final report to the President — and two CHOP-involved initiatives announced their commitments to the Moonshot’s call to action. CHOP hemophilia researchers took a look under the hood of how cells respond to protein infusions to treat this bleeding disorder, finding that one key protein behaved in the exact opposite way it was expected to. And look both ways for what might be some shiny chrome speeding our way in the form of the 2017 Franklin Medal. The recipient of this prestigious award in life sciences was announced this week to be a CHOP scientist who is world renowned as the founder of the field of mitochondrial medicine. Check out more on all of these stories below.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-news-cancer-moonshot-yields-data-sharing-initiatives-hemophilia-surprise-mitochondrial-medal/

Oct 19 2016

Research in Motion to Curb Cell Phone Use While Driving

cell phoneAs you’re driving down the expressway, your cell phone pings, and you glance down at an incoming text message from your best friend. Next thing you know, your car slams the guardrail. The crash leaves you with a severe concussion and a serious lesson learned about distracted driving.

Even though most of us know that using a handheld cell phone while driving is dangerous, we still keep doing it. The availability of more and more of our favorite cell phone functions — texting, checking email, playing music, looking up directions, and posting on social media — poses an ever-present temptation. This is especially true for young drivers, whose adolescent minds are cognitively wired towards instant gratification. A 2015 national survey of 1,243 high school students funded by the National Institutes of Health found that 83 percent reported engaging in electronic device use while driving at least once in the last 30 days.

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Permanent link to this article: http://blog.research.chop.edu/research-motion-curb-cell-phone-use-driving/

Oct 17 2016

A Conversation With Drs. Bryan Wolf and Peter Adamson on Cancer Moonshot


By Bryan A. Wolf, MD, PhD, Chief Scientific Officer and Director of the Research Institute

Every space flight mission requires a carefully planned trajectory, and similarly the national Cancer Moonshot initiative needed a scientific roadmap to reach its ambitions of accelerating the prevention, diagnosis, and treatment of cancer to make a decade of progress in the next five years. In September, Peter Adamson, MD, an oncologist at the Children’s Hospital of Philadelphia and an internationally recognized leader in pediatric cancer drug development who also chairs the Children’s Oncology Group (COG), joined other thought leaders in the cancer research community as a member of the Blue Ribbon Panel (BRP) for the National Cancer Institute (NCI) to issue 13 recommendations for the Cancer Moonshot. Three of the BRP’s recommendations focus on childhood cancer. In this Q&A with Dr. Adamson, let’s take a look at how they intersect with ongoing research at CHOP.

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Permanent link to this article: http://blog.research.chop.edu/conversation-drs-bryan-wolf-peter-adamson-cancer-moonshot/

Oct 14 2016

CHOP Research In the News: Teen Drivers, School Lunches, Dubai Trip, Pregnancy Screening, Drug Safety

CHOP Research In the NewsResearch at the Children’s Hospital of Philadelphia reaches all corners of the world. This week’s In the News takes us on the road with new teen driving safety research findings. Next, we visit school cafeterias for National School Lunch Week. And then we’re off to Dubai for a symposium on special education. Keep going to read more research news on pregnancy screening patterns for teens with leukemia and a commentary on the need for more drug trials for children.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-news-teen-drivers-school-lunches-dubai-trip-pregnancy-screening-drug-safety/

Oct 11 2016

CHOP, Penn Researchers Share Progress and Tips for Using mHealth Tools

mHealthThe digital world moves fast. When the digital realm in question is the use of mobile devices, social media, and related technologies in medical research (mHealth), it isn’t always easy for researchers who use these tools to keep pace. And that is why, just a few months after we first highlighted several examples of mHealth projects in a special issue of Bench to Bedside, it’s already time for a quick update.

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Permanent link to this article: http://blog.research.chop.edu/chop-penn-researchers-share-progress-tips-using-mhealth-tools/

Oct 07 2016

CHOP Research In the News: Ear Infection Genetics, Childhood Cancer Heredity, Vaccine Anniversary

CHOP Research In the NewsWelcome back to another weekly roundup of research news from the Children’s Hospital of Philadelphia! Exciting and important pediatric research spans everything from conditions that are common and treatable, such as ear infections, to others more rare and deadly, such as cancer. And then there are vaccines, which have virtually eliminated scores of deadly infectious diseases with now-common childhood preventive care. This week’s stories from CHOP run that whole gamut.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-news-ear-infection-genetics-childhood-cancer-heredity-vaccine-anniversary/

Oct 04 2016

How to Address Four Factors That Limit Gender Equality in Academic Medicine


By Rebecca Ganetzky, MD

Editor’s Note: While the medical community has made great strides in establishing medicine as a field that is inviting and welcoming to women, our guest blogger points out that more work is needed to improve gender equality in the medical communityDr. Ganetsky is a postgraduate genetics research fellow at The Children’s Hospital of Philadelphia and liaison from the Organization of Resident Representatives to the Group of Women in Medicine and Science for the Association of American Medical Colleges (AAMC).

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Permanent link to this article: http://blog.research.chop.edu/address-four-factors-limit-gender-equality-academic-medicine/

Sep 30 2016

CHOP Research In the News: New Era of Genetics, Grant Awards, Texting Cancer Survivors, Baby Teeth and Autism

CHOP Research NewsA new month is about to begin, so it seems fitting that this week’s research highlights have lots of “new” initiatives that we’re excited to report. A new Collaborative will broaden the scope of genetics medicine at The Children’s Hospital of Philadelphia. Three new grants will help CHOP researchers make advances in pediatric cancer. A study is taking a new mHealth approach by using text messages to help cancer survivors stay healthy. And a new national consortium is looking at the chemical composition of lost baby teeth for clues to possible autism risk factors.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-news-new-era-genetics-grant-awards-texting-cancer-survivors-baby-teeth-autism/

Sep 27 2016

Study of Early Reading to Babies Could be a Page-Turner

early readingFrom the moment they’re born until 3 years old, children’s brains grow rapidly, producing 700 new neural connections every second. This a crucial time for parents and caregivers to provide powerful communication with their babies and stimulate brain centers involved with language development and other skills.

Insufficient parent-child verbal interaction is the most likely cause for language delays, which occur in approximately 13 percent of children under the age of 3 according to a recent estimate, especially those living in low-income areas. Looking to decrease these delays, a research team at The Children’s Hospital of Philadelphia is conducting a new study that will test the effects of initiating a literacy program called Reach Out and Read (ROR) in the newborn period, six months sooner than it is standardly begun.

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Permanent link to this article: http://blog.research.chop.edu/study-early-reading-babies-page-turner/

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