Jul 27 2017

CHOP Hosts Deciphering Beckwith-Wiedemann Syndrome Conference

kalish_cropIt was weekend of firsts on many fronts, as physicians, genetic counselors, nurses, researchers, and families gathered July 21–23 at Children’s Hospital of Philadelphia Research Institute for the inaugural Deciphering Beckwith-Wiedemann syndrome (BWS) conference. BWS is a rare overgrowth disorder involving genetic and epigenetic changes that occur approximately every one in 10,500 births.

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Permanent link to this article: http://blog.research.chop.edu/chop-hosts-deciphering-beckwith-wiedemann-syndrome-conference/

Jul 25 2017

A Day in the Life of a CRISSP Scholar

CRISSP Scholar Julie Uchitel

Editor’s Note: The CHOP Research Institute Summer Scholars Program (CRISSP) hosts 25 bright, talented, hard-working undergrads from various universities to participate in a full-time mentored research experience on campus from June to August. The program is supported by a National Institutes of Health grant. This year, we invited CRISSP scholar Julie Uchitel to share some glimpses behind the scenes of a day in the life of a CRISSP student.

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Permanent link to this article: http://blog.research.chop.edu/crissp-day-life/

Jul 18 2017

Do Researchers Need Standardized Dosing for Infant Anticancer Drug Trials?

The Finding:

Researchers from the Children’s Oncology Group (COG) have developed a new standardized dosing method for anticancer drugs in infants to use across all COG clinical trials. This unified method, based on dose banding and organized into tables for different drugs and dose levels, will address the limitations and variability that researchers can encounter in current methods.

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Permanent link to this article: http://blog.research.chop.edu/researchers-need-standardized-dosing-infant-anticancer-drug-trials/

Jul 13 2017

CTL019 Wins FDA Panel Support, Driving with ADHD, High School Football, New Genetic Syndrome, Teen Bone Growth, Missed Nursing Care

CHOP Research In the NewsCAR T-cell therapy tops this week’s research roundup, with news about the experimental immunotherapy designed to re-engineer a patient’s cells to fight cancer making late-breaking and captivating headlines across the nation. Also in this week’s news: Our researchers are continually studying how we can advance the health and safety of teens in new and novel ways, from football games to that first driving license. Read on to get the latest news from Children’s Hospital of Philadelphia Research Institute.

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Permanent link to this article: http://blog.research.chop.edu/ctl019-wins-fda-panel-support-driving-adhd-high-school-football-new-genetic-syndrome-teen-bone-growth-missed-nursing-care/

Jul 11 2017

How Peacekeeper Cells Prevent Autoimmune Disease: Q&A with The Oliver Lab

All living organisms, from our complicated multicellular selves to the tiniest entities inside our bodies, have an identity: a set of vital characteristics that guide our daily routines, give us purpose, and unfortunately – even in the case of our microscopic cells – sometimes get lost. In the lab of Paula Oliver, PhD, associate professor of Pathology at Children’s Hospital of Philadelphia, a group of researchers led by Awo Layman, PhD; Guoping Deng, PhD; and Claire O’Leary, PhD, studied the influential events that transpire when, as Dr. Layman described it to us, a type of immune cell called a regulatory T cell (also known as a Treg cell) suffers a “loss of identity.” Previous research has suggested that Treg cells help protect us from autoimmune disease, but little is known about how their identity is maintained so that they can continue to perform these key roles. We sat down with Drs. Layman and Deng to discuss the fascinating story of their most recent findings, published in Nature Communications, about one key protein that helps Treg cells maintain their character.

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Permanent link to this article: http://blog.research.chop.edu/peacekeeper-cells-prevent-autoimmune-disease-qa-oliver-lab/

Jul 05 2017

On the Record: Student Reporters Celebrate Community Health Leaders

Press badges in hand, the fourth and fifth-grade reporters of Philadelphia’s local schools are taking today’s news coverage about health and science into their own communities.

As part of the educational program Healthy NewsWorks, young journalists from the Highland Park Healthy Hawk, the East Norriton Bulldog Bulletin, and other student-run newspapers interviewed clinicians and researchers about some of today’s most pressing health topics from gun violence to preventing sports injuries to city health programs for the uninsured. This year’s Healthy Newswork network of “health leaders” includes our own Paul Offit, MD, director of the Vaccine Education Center at Children’s Hospital of Philadelphia, and Senbagam Virudachalam, MD, pediatrician and PolicyLab faculty member.

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Permanent link to this article: http://blog.research.chop.edu/record-student-reporters-celebrate-community-health-leaders/

Jun 30 2017

Measuring Flexible Thinking, Managing Concussions, Tech Addiction, 2017 Pew Scholar, U.S. News & World Report

CHOP Research In the NewsEvery good researcher needs a sturdy set of tools: Whether it’s a new technology that drives efficiency, the financial support that accompanies an award, or simple advice from a research mentor, all of these resources make collective breakthroughs possible. This week in research news at Children’s Hospital of Philadelphia, read about how our investigators helped design new tools to measure cognitive flexibility, studied the usefulness of electronic tools in the CHOP EPIC health record system, and received prestigious honors that provide them with the resources to drive children’s health forward.

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Permanent link to this article: http://blog.research.chop.edu/in-the-news-measuring-flexible-thinking-managing-concussions-tech-addiction-2017-pew-scholar-u-s-news-world-report/

Jun 29 2017

Children Have the Most to Lose in Proposed Medicaid Cuts

Editor’s Note: This guest blog by David Rubin, MD, MSCE, director of Children’s Hospital of Philadelphia’s PolicyLab, discusses how deep Medicaid cuts could harm children and teens. (This text originally appeared in a PolicyLab newsletter. If you’re interested in receiving their newsletter, please visit their website to sign up.) In a previous post, Dr. Rubin reported on PolicyLab research that showed many low- and moderate-income working families rely entirely on Medicaid and the Children’s Health Insurance Program to provide cost-effective and comprehensive coverage for their children. The maintenance and protection of these programs is now more important than ever, yet the Senate and House are considering legislation that would leave many families vulnerable to gaps in coverage and benefits.

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Permanent link to this article: http://blog.research.chop.edu/children-lose-proposed-medicaid-cuts/

Jun 28 2017

U.S. News National Survey Ranks CHOP Specialty Areas in Top Ten

Three cheers for our Children’s Hospital of Philadelphia team for once again achieving outstanding rankings in the U.S. News & World Report 11th annual Best Children’s Hospitals rankings. CHOP earned second place on the Honor Roll, a distinction awarded to pediatric centers that deliver exceptionally high-quality care across multiple specialties.

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Permanent link to this article: http://blog.research.chop.edu/u-s-news-national-survey-ranks-chop-specialty-areas-top-ten/

Jun 27 2017

Let’s Talk: A Q&A About How to Engage in Shared Decision-making

susan_levy_cropMaking medical decisions can be overwhelming when families must figure out the “best choices” for their child who may have special healthcare needs or developmental disabilities. Some families may rely on their clinicians to make these important decisions for them, in a paternalistic “father knows best” way. Other families may see themselves as consumers and carry strong opinions about a certain treatment approach they came across yesterday on the Internet. Recognizing that physicians must navigate such a wide variation of family values, expectations, and priorities, Susan Levy, MD, MPH, a developmental pediatrician and researcher for the Center for Autism Research at Children’s Hospital of Philadelphia, co-authored an American Academy of Pediatrics (AAP) clinical report on behalf its Council on Children with Disabilities to provide a framework for the implementation of shared decision-making.

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Permanent link to this article: http://blog.research.chop.edu/lets-talk-qa-engage-shared-decision-making/

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