Feb 09 2016

CHOP Research Annual Report 2015: The Future Is Here — Don’t Miss It

CHOP Research 2015 Annual Report

By Bryan A. Wolf, MD, PhD, Chief Scientific Officer and Director of the Research Institute

Scientific minds are imagining. Sophisticated machines are harnessing genetic data. An invisible universe of microbes is revealing new insights into disease. Discoveries are changing children’s worlds. Every second of every day is filled with wonder at The Children’s Hospital of Philadelphia Research Institute. Our Annual Report captures many of these moments and shares how they contributed to our tremendous success in 2014-2015.

For the first time, our Annual Report features an impressive video introduction. You will see how the pioneering work of our investigators, whether in the laboratory or the clinic, has improved the lives of countless children everywhere. And you will hear why I am so enthusiastic about leading our team of scientific innovators into the next era of pediatric healthcare.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-annual-report-2015-the-future-is-here-dont-miss-it/

Feb 08 2016

Administration Fellowship Opens Doors for Early Career Researchers

administration fellowshipThe latest translational research project for Rajarshi Sengupta, PhD, just might be his own career. He was inspired to look beyond his current work as a staff scientist at The Children’s Hospital of Philadelphia Research Institute to get a better perspective of how administrators support clinical research. He will have the opportunity to do so because leaders of the Research Institute’s Office of Postdoctoral Affairs selected Dr. Sengupta as a Research Administration Fellow.

“I’ve always done research that’s kind of translational, kind of close to clinical work,” said Dr. Sengupta, who works in the lab of Robert Heuckeroth, MD, PhD, at CHOP studying the development and disorders of the enteric nervous system. “Taking things from bench to bedside takes a long time, though. People who facilitate clinical and translational research as administrators can see the impact of that work on a much shorter time frame than I can with what I’m doing in the lab. That is satisfying, being part of a team that makes things happen for patients.”

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Permanent link to this article: http://blog.research.chop.edu/administration-fellowship-opens-doors-for-early-career-researchers/

Feb 05 2016

CHOP Research In the News: Triple-Threat Cancer Gene, Autism and Faces

CHOP Research In the NewsCancer genetics and collaboration were big themes in this week’s news featuring research at The Children’s Hospital of Philadelphia. Check out our weekly summary of some of the developments this first week of February, below.

Triple-Threat Fused Gene Found Driving Pediatric Brain Tumors

An international team has discovered an abnormal fused gene that drives pediatric brain tumors and poses a triple threat, operating simultaneously through three distinct biological mechanisms — the first such example in cancer biology.

“The gene rearrangement we investigated offers a great candidate for a precision medicine approach in improving treatment for children with this type of brain tumor,” said Adam Resnick, PhD, a neuro-oncology researcher in the division of Neurosurgery at CHOP, who co-led the study published this week in Nature Genetics. “Our research exemplifies the transformative power of large multi-institutional research collaborations in sharing and empowering data from new diagnostic technologies.”

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Permanent link to this article: http://blog.research.chop.edu/chop-research-in-the-news-triple-threat-cancer-gene-autism-and-faces/

Feb 04 2016

Innovators Win Grants to Support Pediatric Medical Device Development

pediatric medical deviceThe Philadelphia Pediatric Medical Device Consortium (PPDC) provides know-how and seed funding to help innovators translate concepts into commercial medical devices for use in children. In the PPDC’s latest round of awards, two companies out of 27 applicants received grants of $50,000 each.

“We are excited to provide these funds to innovators of promising medical devices that will address unmet clinical needs of pediatric patients around the world,” said bioengineer Matthew Maltese, PhD, of The Children’s Hospital of Philadelphia, the Consortium’s executive director and principal investigator.

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Permanent link to this article: http://blog.research.chop.edu/innovators-win-grants-to-support-pediatric-medical-device-development/

Feb 02 2016

Scientists Discover a Better ALK Inhibitor to Treat Neuroblastoma

neuroblastomaPediatric cancer researchers at The Children’s Hospital of Philadelphia believe they have succeeded in their search for a powerful next-generation drug for neuroblastoma tumors with mutations in the anaplastic lymphoma kinase (ALK) gene associated with the cancer. Based on their preclinical findings, they are fast-tracking the launch of a clinical trial this year.

Usually appearing as a solid tumor in the chest or abdomen, neuroblastoma accounts for a disproportionate share of cancer deaths in children, despite many recent improvements in therapy.

The search for better ALK inhibitors originated when, in 2008, CHOP pediatric oncologist Yael Mossé, MD, and colleagues identified ALK mutations as a driver of most cases of rare, inherited neuroblastoma. Subsequent research showed that abnormal ALK changes drive approximately 14 percent of high-risk forms of neuroblastoma.

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Permanent link to this article: http://blog.research.chop.edu/scientists-discover-a-better-alk-inhibitor-to-treat-neuroblastoma/

Jan 29 2016

CHOP Research In the News: Fetal Imaging, Hoverboards, and Violence

CHOP Research In the NewsViolence Against Children: An Urgent Public Health Priority

Violence against children has reached an epidemic level globally, according to a new study published in the journal Pediatrics and reported by CBS News.

A team from the U.S. Centers for Disease Control and Prevention (CDC) and Massachusetts General Hospital/Harvard Medical School analyzed 38 reports covering 96 countries and estimated that at least 50 percent of children in Asia, Africa, and North America experienced past-year violence, as did more than 30 percent of children in Latin America.

The study was well done and very strong, according to Joel Fein, MD, MPH, co-director of the Emergency Department Violence Intervention Project at The Children’s Hospital of Philadelphia and The University of Pennsylvania Medical Center, and Stephen Leff, PhD, a psychologist in the department of Child and Adolescent Psychiatry and Behavioral Sciences and co-director of the Violence Prevention Initiative (VPI) at CHOP, who were quoted in the CBS News report.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-in-the-news-12916/

Jan 28 2016

Precision Medicine Initiatives, Medical Mysteries in Bench to Bedside

Bench to BedsideA blizzard of research happenings and news — from initiatives that are pushing precision medicine forward to a new way of thinking about how cancer progresses — appear in the January issue of Bench to Bedside, The Children’s Hospital of Philadelphia Research Institute’s monthly newsmagazine. Here are five intriguing quotes that will make you want to dig into the articles and read more:

How Precision Medicine is Reshaping Epilepsy Research

“Most drugs for epilepsy work like treating pneumonia with a cough suppressant: It may stop the symptom but doesn’t treat the underlying problem,” said Ethan Goldberg, MD, PhD, a CHOP neurologist and neuroscientist.

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Permanent link to this article: http://blog.research.chop.edu/precision-medicine-initiatives-medical-mysteries-in-bench-to-bedside/

Jan 26 2016

Positive Adult Connections Play Protective Role for At-Risk Youth

Positive Adult ConnectionAn adolescent’s life is full of ups and downs, and research has shown that it can be helpful for them to have adults who they can turn to in times of trouble. Unfortunately, youth living in low resource urban neighborhoods may face adversity on a daily basis, which means that these positive adult connections can be especially valuable to them.

In fact, a new study conducted by researchers at The Children’s Hospital of Philadelphia shows that when adolescents in low resource urban environments have adults in their lives who they look up to and can help them handle tough situations, these mentors can have profound protective effects on their development. For many youth, family members can serve in this role, and for others, teachers, community leaders, or clergy can provide this support.

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Permanent link to this article: http://blog.research.chop.edu/positive-adult-connections-play-protective-role-for-at-risk-youth/

Jan 25 2016

CHOP Research In the News

CHOP Research NewsResearch at The Children’s Hospital of Philadelphia never stops. To help keep you informed about new discoveries and CHOP researchers’ views on timely topics, we are bringing together a roundup of news highlights. Look for this as a recurring feature here on Cornerstone.

Cancer Moonshot Launches with Penn and CHOP Researchers

The big news last week was Vice President Joe Biden’s visit to the Abramson Cancer Center at the University of Pennsylvania Jan. 15 for the launch of the “Moonshot” initiative to accelerate discovery of cancer treatments and cures.

The Vice President reportedly chose the venue in recognition of recent Penn/CHOP team successes with precision immunotherapies, which also featured prominently this week in a Philadelphia Inquirer article about precision medicine.

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Permanent link to this article: http://blog.research.chop.edu/chop-research-news-this-week-cancer-moonshot-autism-genes-gene-transfer/

Jan 20 2016

New Director of Pediatric Research in Office Settings Network

Alexander FiksAlexander Fiks, MD, MSCE, a primary care pediatrician at The Children’s Hospital of Philadelphia, wears many hats, and he is adding one more with his recent appointment as director of the American Academy of Pediatrics’ Pediatric Research in Office Settings (PROS) network, which includes more than 700 U.S. practices.

When a pediatrician wonders whether a particular facet of day-to-day pediatric care delivery is useful and effective, PROS can help turn that question into a project that can be researched throughout the network to improve children’s health.

“Through this process, our research can be most responsive to the need of practices, practitioners, and the families they serve,” Dr. Fiks said.

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Permanent link to this article: http://blog.research.chop.edu/new-director-of-pediatric-research-in-office-settings-network/

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