Oct 20 2017

Flaura Winston NAM Election, Philadelphia Pediatric Medical Device Consortium, SeeIV, Boyle Scientific Achievement Award

CHOP Research In the NewsAt Children’s Hospital of Philadelphia, our investigators are continuously helping to develop evidence-based technology that will improve the way we care for and protect children’s health. And in this week’s headlines, we’re seeing that happen in more ways than one. From the creation of devices that will make the lives of clinicians and patients easier, to providing seed grants for novel innovations through the Philadelphia Pediatric Medical Device Consortium, to informing safe practices for technology through renowned organizations like the National Academy of Medicine, we invite you to keep reading to learn what our researchers are up to! 

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Permanent link to this article: http://blog.research.chop.edu/in-the-news-flaura-winston-nam-election-philadelphia-pediatric-medical-device-consortium-seeiv-boyle-scientific-achievement-award/

Oct 16 2017

Research Family Partners Program Brings New Dimension to Research Studies


Editor’s Note: Our guest blogger, Amy Kratchman, has been working with clinicians and researchers since 2008 as a family representative. She is the mother of three children with special healthcare needs. As a family consultant at Children’s Hospital of Philadelphia, Kratchman co-leads numerous family-centered care initiatives. She collaborates with senior hospital leaders and staff to ensure that the institution’s operating plan and programmatic goals are responsive to the needs of children and families. Kratchman co-leads Family Partners, an innovative program developed and implemented at CHOP, to maximize the meaningful engagement of families in all aspects of the pediatric healthcare delivery system. Engaging parents and youth in research is a major focus of this work.

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Permanent link to this article: http://blog.research.chop.edu/research-family-partners-program-brings-new-dimension-research-studies/

Oct 13 2017

Translational Research Workshop Bridges Gap Between Bench Research and Clinic

If you glance at a diagram of the continuum of translational research, the arrows point orderly to five phases — from basic research to improving population health. Rarely, however, is the business of discovery so neatly aligned. It takes unexpected twists and turns, as attendees at this week’s Children’s Hospital of Philadelphia Translational Research Workshop for Basic Scientists heard from experienced investigators who shared lessons that they’ve learned while pursuing their scientific endeavors.

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Permanent link to this article: http://blog.research.chop.edu/translational-research-workshop-bridges-gap-bench-research-clinic/

Oct 11 2017

Mind Meets Body in New Lupus Research: Q & A With Andrea Knight, Rheumatology Physician

When children have lupus, they often deal with more than just the physical burden of the autoimmune condition. Along with the swollen joints, skin rashes, ulcers, kidney disease and chest pain common to lupus, many of our pediatric patients also carry with them depression, anxiety, memory problems, and brain fog – all of which can adversely affect their school and social lives. As the recipient of a Novel Research Grant from the Lupus Research Alliance, Andrea Knight, MD, a physician in the division of Rheumatology, is working to better understand why children with systemic lupus erythematosus (SLE) experience mental health problems. Novel Research Grants aim to support investigators in early stage research projects that involve “creative and innovative approaches” to major issues in lupus, according to the research alliance’s website.

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Permanent link to this article: http://blog.research.chop.edu/mind-meets-body-new-lupus-research-q-andrea-knight-rheumatology-physician/

Oct 09 2017

From Baking to Biomedicine: Nick Pautler Won’t Let ALL Define Him

Editor’s Note: This occasional blog series features stories of CHOP research heroes who have participated in clinical research studies. Without the generosity and dedication of families, patients, and members of the public who take the time to be a part of research, many trials would not succeed.

Nick Pautler, a biomedical engineering student at the University of Delaware, can tell you how a lot of things work – from the microbial science behind baking sourdough bread, to the intricacy of model railroads, to the way that an army of re-engineered T-cells worked hard to fight the cancer cells in his body this past year.

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Permanent link to this article: http://blog.research.chop.edu/research-heros-from-baking-to-biomedicine-nick-pautler-wont-let-all-define-him/

Oct 06 2017

Neuroblastoma Gene Variants, Center for GI Motility Expansion, Improving Autism Diagnosis, Fontan Procedure Follow-Ups

CHOP Research In the NewsThis week, new research findings at Children’s Hospital of Philadelphia are propelling the way we think about autism, single ventricle survivors, and neuroblastoma forward, as our investigators continued to push the boundaries of what we know. At the Center for Autism Research (CAR), researchers shared why novel observations about the linguistic differences between girls and boys with autism matter when making a diagnosis. Meanwhile, a pediatric oncologist and an expert in genomics teamed up to strengthen our understanding of the genetic construction behind neuroblastoma, a complex cancer. The headlines continue as PolicyLab researchers conducted important investigations into maltreatment in military families, and cardiologists took a hard look at the long-term outcomes for Fontan procedure survivors. With every new discovery that could lead to a new way of caring for children, we are reminded that pediatric science is as fluid and ever-changing as our October weather!

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Permanent link to this article: http://blog.research.chop.edu/in-the-news-neuroblastoma-gene-variants-center-gi-motility-expansion-improving-autism-diagnosis-fontan-procedure-follow-ups/

Oct 03 2017

What Are Transcription Errors’ Role in Aging and Disease?

snapshot science

Why this study is important:

The human genome provides a precise, biological blueprint of life. To implement this blueprint correctly, the genome must be read with great precision, but it’s impossible for this process to be completely error-free. Mistakes during transcription — random errors in how DNA sequences are copied for a gene to be expressed — can happen any time in any number of ways. Research suggests that the error rate of transcription increases as cells age, yet how these transcription errors affect cellular health remains a mystery.

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Permanent link to this article: http://blog.research.chop.edu/snapshot-science-transcription-errors-role-aging-disease/

Sep 29 2017

Researchers Win Grants to Explore New Drug Targets for Childhood Cancers

National Childhood Cancer Awareness Month is coming to a close, but new research endeavors are continuing the momentum and driving toward better treatment options. Hyundai Hope On Wheels awarded two pediatric cancer investigators at Children’s Hospital of Philadelphia research grants during a Celebration of Life Gala held Sept. 27 in Philadelphia.

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Permanent link to this article: http://blog.research.chop.edu/researchers-win-grants-explore-new-drug-targets-childhood-cancers/

Sep 26 2017

Bringing it All Together: Organization Skills for Upper Elementary Students

Summer vacation is over, and the kids have strapped on their backpacks and headed back to school for what parents and teachers hope will be a fruitful year. Running down the checklist of what students need to be successful in school, we’ll find notebooks, pencils, a calculator, and . . . executive functioning?

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Permanent link to this article: http://blog.research.chop.edu/bringing-together-organization-skills-upper-elementary-students/

Sep 22 2017

AAP Conference, PCORI Sickle Cell Research, Eagles Autism Challenge, Anxiety and Autism, New Immunotherapy Target for Neuroblastoma

CHOP Research In the NewsNotable awards, new autism initiatives, and a novel approach to managing sickle cell disease are all part of this week’s roundup of research news. As Children’s Hospital of Philadelphia experts made waves at the American Academy of Pediatrics (AAP) National Conference in Chicago, our local Philadelphia Eagles launched a new commitment to support autism research at CHOP and neighboring institutions back home. Read on to learn more about the latest headlines in CHOP research – including the detection of a potential immunotherapy target for neuroblastoma.

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Permanent link to this article: http://blog.research.chop.edu/in-the-news-aap-conference-pcori-sickle-cell-research-eagles-autism-challenge-anxiety-autism-new-immunotherapy-target-neuroblastoma/

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